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HAND1 sirna

Scan QR to view Datasheet Catalog #    MBS8212883 HAND1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HAND1, siRNA

 Also Known As   

HAND1 siRNA (Mouse)

 Product Synonym Names    EHAND; HXT; THING1; Heart- and neural crest derivatives-expressed protein 1; Extraembryonic tissues. heart. autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND; Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast; Thing-1; Th1
 Product Gene Name   

HAND1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q64279
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    HAND1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse HAND1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of HAND1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HAND1 sirna

   siRNA to inhibit HAND1 expression using RNA interference
 Applications Tested/Suitable for HAND1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for HAND1. It may not necessarily be applicable to this product.
 NCBI GI #    6680165
 NCBI GeneID    15110
 NCBI Accession #    NP_032239.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008213.2 [Other Products]
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 UniProt Primary Accession #    Q64279 [Other Products]
 UniProt Secondary Accession #    Q61099 [Other Products]
 UniProt Related Accession #    Q64279 [Other Products]
 Molecular Weight    23,806 Da
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 NCBI Official Full Name    heart- and neural crest derivatives-expressed protein 1
 NCBI Official Synonym Full Names    heart and neural crest derivatives expressed transcript 1
 NCBI Official Symbol    Hand1 [Similar Products]
 NCBI Official Synonym Symbols   
Hxt; Th1; eHAND; Ehand1; Thing1; bHLHa27
[Similar Products]
 NCBI Protein Information    heart- and neural crest derivatives-expressed protein 1
 UniProt Protein Name    Heart- and neural crest derivatives-expressed protein 1
 UniProt Synonym Protein Names   
Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; eHAND; Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast; Thing-1; Th1
 Protein Family    Heart- and neural crest derivatives-expressed protein
 UniProt Gene Name    Hand1 [Similar Products]
 UniProt Synonym Gene Names    Ehand; Hxt; Thing1; eHAND; Th1 [Similar Products]
 UniProt Entry Name    HAND1_MOUSE
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 UniProt Comments for HAND1    HAND1: Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box).

Protein type: DNA-binding; Cell development/differentiation; Transcription factor; Nucleolus

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: protein dimerization activity; identical protein binding; protein binding; enzyme binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription coactivator activity; bHLH transcription factor binding; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; heart morphogenesis; transcription, DNA-dependent; in utero embryonic development; negative regulation of transcription factor activity; heart development; positive regulation of transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; odontogenesis of dentine-containing teeth; mesoderm formation; regulation of transcription, DNA-dependent; embryonic heart tube development; ventricular cardiac muscle morphogenesis; positive regulation of transcription from RNA polymerase II promoter; heart looping; angiogenesis; negative regulation of transcription, DNA-dependent; cell differentiation
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 Research Articles on HAND1    1. Re-expression of HAND1 in colon cancer cells induces terminal differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HAND1 sirnaPathways associated with HAND1 sirna
 Reference Product  PubMed Publications
 Hand2 sirna  >56 publications with HAND1 and Hand2
 Nkx2-5 sirna  >26 publications with HAND1 and Nkx2-5
 Gata4 sirna  >22 publications with HAND1 and Gata4
 Tcf3 sirna  >12 publications with HAND1 and Tcf3
 Mef2c sirna  >6 publications with HAND1 and Mef2c
 Tcf12 sirna  >2 publications with HAND1 and Tcf12
 Phox2b sirna  >2 publications with HAND1 and Phox2b
 Products by Pathway  Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
Diseases associated with HAND1 sirnaOrgans/Tissues associated with HAND1 sirna
 Disease Name  Pubmed Publications
 Heart Defects, Congenital Antibodies  >22 publications with HAND1 and Heart Defects, Congenital
 Disease Models, Animal Antibodies  >9 publications with HAND1 and Disease Models, Animal
 Abnormalities, Multiple Antibodies  >5 publications with HAND1 and Abnormalities, Multiple
 Neoplasms, Experimental Antibodies  >3 publications with HAND1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >2 publications with HAND1 and Liver Diseases
 Inflammation Antibodies  >2 publications with HAND1 and Inflammation
 Brain Diseases Antibodies  >2 publications with HAND1 and Brain Diseases
 Necrosis Antibodies  >2 publications with HAND1 and Necrosis
 Learning Disorders Antibodies  >1 publications with HAND1 and Learning Disorders
 Fibrosis Antibodies  >1 publications with HAND1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >104 publications with HAND1 and Heart
 Embryonic Tissue Antibodies  >65 publications with HAND1 and Embryonic Tissue
 Extraembryonic Tissue Antibodies  >8 publications with HAND1 and Extraembryonic Tissue
 Sympathetic Ganglion Antibodies  >3 publications with HAND1 and Sympathetic Ganglion
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