NP_037317.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,968 Da
NCBI Official Full Name
tyrosine-protein kinase HCK
NCBI Official Synonym Full Names
hemopoietic cell kinase
NCBI Protein Information
tyrosine-protein kinase HCK
UniProt Protein Name
Tyrosine-protein kinase HCK
UniProt Synonym Protein Names
Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK; p56Hck; p59Hck
UniProt Entry Name
HCK_RAT
NCBI Summary for HCK
The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types.The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms in human and mouse. Based on strong sequence conservation amongst these species, this may also be true for rat. [provided by RefSeq, Jul 2008]
UniProt Comments for HCK
Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.
Protein type: Oncoprotein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Src family
Cellular Component: Golgi apparatus; transport vesicle; extrinsic to internal side of plasma membrane; cell projection; focal adhesion; lysosome; actin filament; caveola; nucleus; cytosol
Molecular Function: protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: exocytosis; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cytoskeleton organization and biogenesis; regulation of phagocytosis; phagocytosis; regulation of cell proliferation; regulation of cell shape; defense response to Gram-positive bacterium; regulation of transcription factor activity; positive regulation of cell proliferation; innate immune response; cell differentiation; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
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Products associated with HCK sirna
Pathways associated with HCK sirna
Diseases associated with HCK sirna
Organs/Tissues associated with HCK sirna
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