NP_001263183.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,992 Da
NCBI Official Full Name
interferon lambda-4
NCBI Official Synonym Full Names
interferon, lambda 4 (gene/pseudogene)
NCBI Official Synonym Symbols
NCBI Protein Information
interferon lambda-4
UniProt Protein Name
Interferon lambda-4
UniProt Synonym Gene Names
UniProt Entry Name
IFNL4_HUMAN
UniProt Comments for IFNL4
IFNL4: Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes. Belongs to the lambda interferon family. Up-regulated by polyinosinic:polycytidylic acid (polyI:C) which mimics double-stranded hepatitis C virus. 4 isoforms of the human protein are produced by alternative splicing
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: extracellular space; cytoplasm
Molecular Function: cytokine activity
Biological Process: positive regulation of immune response; tyrosine phosphorylation of Stat2 protein; tyrosine phosphorylation of Stat1 protein; defense response to virus
Research Articles on IFNL4
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