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IFNL4 sirna

Scan QR to view Datasheet Catalog #    MBS8234790 IFNL4 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IFNL4, siRNA

★Popular Item★
 Also Known As   

IFNL4 siRNA (Human)

 Product Synonym Names    Interferon lambda-4; IFN-lambda-4
 Product Gene Name   

IFNL4 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    615090
 3D Structure    ModBase 3D Structure for K9M1U5
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 Species Reactivity    Human
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 Specificity    IFNL4 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Source    Synthetic
 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human IFNL4 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of IFNL4 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IFNL4 sirna

   siRNA to inhibit IFNL4 expression using RNA interference
 Applications Tested/Suitable for IFNL4 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for IFNL4. It may not necessarily be applicable to this product.
 NCBI GI #    482513660
 NCBI GeneID    101180976
 NCBI Accession #    NP_001263183.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001276254.2 [Other Products]
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 UniProt Primary Accession #    K9M1U5 [Other Products]
 UniProt Secondary Accession #    K9M1A5; K9M269; K9M2P7 [Other Products]
 UniProt Related Accession #    K9M1U5 [Other Products]
 Molecular Weight    11,992 Da
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 NCBI Official Full Name    interferon lambda-4
 NCBI Official Synonym Full Names    interferon, lambda 4 (gene/pseudogene)
 NCBI Official Symbol    IFNL4 [Similar Products]
 NCBI Official Synonym Symbols   
IFNAN
[Similar Products]
 NCBI Protein Information    interferon lambda-4
 UniProt Protein Name    Interferon lambda-4
 Protein Family    Interferon
 UniProt Gene Name    IFNL4 [Similar Products]
 UniProt Synonym Gene Names    IFN-lambda-4 [Similar Products]
 UniProt Entry Name    IFNL4_HUMAN
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 UniProt Comments for IFNL4    IFNL4: Cytokine that may trigger an antiviral response activating the JAK-STAT pathway and up-regulating specifically some interferon-stimulated genes. Belongs to the lambda interferon family. Up-regulated by polyinosinic:polycytidylic acid (polyI:C) which mimics double-stranded hepatitis C virus. 4 isoforms of the human protein are produced by alternative splicing

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: cytokine activity

Biological Process: positive regulation of immune response; tyrosine phosphorylation of Stat2 protein; tyrosine phosphorylation of Stat1 protein; defense response to virus
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 Research Articles on IFNL4    1. this review summarizes the current knowledge of IFN-l4 and discusses questions that should be addressed to resolve its paradoxical biologic activities.[review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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