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IGF2R sirna

Scan QR to view Datasheet Catalog #    MBS8214144 IGF2R sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF2R, siRNA

★Popular Item★
 Also Known As   

IGF2R siRNA (Mouse)

 Product Synonym Names    Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD antigen CD222
 Product Gene Name   

IGF2R sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q07113
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    IGF2R siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse IGF2R gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of IGF2R sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IGF2R sirna

   siRNA to inhibit IGF2R expression using RNA interference
 Applications Tested/Suitable for IGF2R sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for IGF2R. It may not necessarily be applicable to this product.
 NCBI GI #    133778978
 NCBI GeneID    16004
 NCBI Accession #    NP_034645.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_010515.2 [Other Products]
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 UniProt Primary Accession #    Q07113 [Other Products]
 UniProt Secondary Accession #    Q61822; Q6LED1 [Other Products]
 UniProt Related Accession #    Q07113 [Other Products]
 Molecular Weight    273,815 Da
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 NCBI Official Full Name    cation-independent mannose-6-phosphate receptor
 NCBI Official Synonym Full Names    insulin-like growth factor 2 receptor
 NCBI Official Symbol    Igf2r [Similar Products]
 NCBI Official Synonym Symbols   
CD222; CI-MPR; Mpr300; AI661837; M6P/IGF2R
[Similar Products]
 NCBI Protein Information    cation-independent mannose-6-phosphate receptor
 UniProt Protein Name    Cation-independent mannose-6-phosphate receptor
 UniProt Synonym Protein Names   
300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD_antigen: CD222
 Protein Family    Cation-independent mannose-6-phosphate receptor
 UniProt Gene Name    Igf2r [Similar Products]
 UniProt Synonym Gene Names    CI Man-6-P receptor; CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R [Similar Products]
 UniProt Entry Name    MPRI_MOUSE
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 UniProt Comments for IGF2R    IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.

Protein type: Vesicle; Receptor, misc.; Membrane protein, integral

Cellular Component: extracellular space; focal adhesion; cell surface; clathrin coat; lysosome; integral to membrane; trans-Golgi network; trans-Golgi network transport vesicle; membrane; endocytic vesicle; nuclear envelope lumen; perinuclear region of cytoplasm; late endosome; cytoplasm; plasma membrane; nucleus; endosome

Molecular Function: G-protein coupled receptor activity; insulin-like growth factor binding; identical protein binding; mannose binding; enzyme binding; retinoic acid binding; transporter activity; G-protein alpha-subunit binding; phosphoprotein binding; glycoprotein binding; insulin-like growth factor II binding

Biological Process: regulation of apoptosis; G-protein coupled receptor protein signaling pathway; response to retinoic acid; transport; positive regulation of apoptosis; liver development
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 Research Articles on IGF2R    1. that an elevation in IGF-II receptor levels can influence the expression profiles of transcripts as well as proteins that are involved in AD pathogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF2R sirnaPathways associated with IGF2R sirna
 Reference Product  PubMed Publications
 M6pr sirna  >1848 publications with IGF2R and M6pr
 Igf2 sirna  >257 publications with IGF2R and Igf2
 Mest sirna  >29 publications with IGF2R and Mest
 Rab9 sirna  >16 publications with IGF2R and Rab9
 Dnmt1 sirna  >12 publications with IGF2R and Dnmt1
 Gga1 sirna  >9 publications with IGF2R and Gga1
 Gga3 sirna  >8 publications with IGF2R and Gga3
 Gnas sirna  >6 publications with IGF2R and Gnas
 Gga2 sirna  >5 publications with IGF2R and Gga2
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 PI3K/Akt/mTOR Signaling Pathway antibodies  PI3K/Akt/mTOR Signaling Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram
Diseases associated with IGF2R sirnaOrgans/Tissues associated with IGF2R sirna
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >118 publications with IGF2R and Nervous System Diseases
 Liver Diseases Antibodies  >85 publications with IGF2R and Liver Diseases
 Liver Neoplasms Antibodies  >78 publications with IGF2R and Liver Neoplasms
 Breast Neoplasms Antibodies  >64 publications with IGF2R and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >54 publications with IGF2R and Carcinoma, Hepatocellular
 Death Antibodies  >52 publications with IGF2R and Death
 Neoplasms, Experimental Antibodies  >48 publications with IGF2R and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >45 publications with IGF2R and Cardiovascular Diseases
 Kidney Diseases Antibodies  >40 publications with IGF2R and Kidney Diseases
 Congenital Abnormalities Antibodies  >34 publications with IGF2R and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >296 publications with IGF2R and Liver
 Blood Antibodies  >236 publications with IGF2R and Blood
 Muscle Antibodies  >174 publications with IGF2R and Muscle
 Brain Antibodies  >161 publications with IGF2R and Brain
 Embryonic Tissue Antibodies  >148 publications with IGF2R and Embryonic Tissue
 Ovary Antibodies  >93 publications with IGF2R and Ovary
 Heart Antibodies  >93 publications with IGF2R and Heart
 Lung Antibodies  >77 publications with IGF2R and Lung
 Bone Antibodies  >62 publications with IGF2R and Bone
 Skin Antibodies  >45 publications with IGF2R and Skin
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