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IL1A sirna

Scan QR to view Datasheet Catalog #    MBS8200312 IL1A sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL1A, siRNA

★Popular Item★
 Also Known As   

IL1A siRNA (Mouse)

 Product Synonym Names    Interleukin-1 alpha; IL-1 alpha
 Product Gene Name   

IL1A sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P01582
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    IL1A siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse IL1A gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of IL1A sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL1A sirna

   siRNA to inhibit IL1A expression using RNA interference
 Applications Tested/Suitable for IL1A sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for IL1A. It may not necessarily be applicable to this product.
 NCBI GI #    47059075
 NCBI GeneID    16175
 NCBI Accession #    NP_034684.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_010554.4 [Other Products]
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 UniProt Primary Accession #    P01582 [Other Products]
 UniProt Related Accession #    P01582 [Other Products]
 Molecular Weight    31,023 Da
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 NCBI Official Full Name    interleukin-1 alpha
 NCBI Official Synonym Full Names    interleukin 1 alpha
 NCBI Official Symbol    Il1a [Similar Products]
 NCBI Official Synonym Symbols   
Il-1a
[Similar Products]
 NCBI Protein Information    interleukin-1 alpha
 UniProt Protein Name    Interleukin-1 alpha
 Protein Family    Interleukin
 UniProt Gene Name    Il1a [Similar Products]
 UniProt Synonym Gene Names    IL-1 alpha [Similar Products]
 UniProt Entry Name    IL1A_MOUSE
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 UniProt Comments for IL1A    IL1A: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family.

Protein type: Motility/polarity/chemotaxis; Cytokine

Cellular Component: extracellular space; cell surface; plasma membrane; extracellular region; cytosol

Molecular Function: interleukin-1 receptor binding; copper ion binding; cytokine activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; germ cell programmed cell death; positive regulation of JNK cascade; positive regulation of interleukin-6 production; fever; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; positive regulation of angiogenesis; connective tissue replacement during inflammatory response; response to copper ion; positive regulation of cell division; keratinization; positive regulation of prostaglandin secretion; immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; inflammatory response; positive regulation of cytokine secretion
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 Research Articles on IL1A    1. it appears the balance between TPO and IL-1alpha determines the MK cellular programming for thrombopoiesis in response to acute and chronic platelet needs.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL1A sirnaPathways associated with IL1A sirna
 Reference Product  PubMed Publications
 Il1b sirna  >209 publications with IL1A and Il1b
 Il1r1 sirna  >16 publications with IL1A and Il1r1
 Myd88 sirna  >4 publications with IL1A and Myd88
 Il1r2 sirna  >3 publications with IL1A and Il1r2
 Irak2 sirna  >2 publications with IL1A and Irak2
 Irak4 sirna  >1 publications with IL1A and Irak4
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
Diseases associated with IL1A sirnaOrgans/Tissues associated with IL1A sirna
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >100 publications with IL1A and Inflammation
 Necrosis Antibodies  >62 publications with IL1A and Necrosis
 Skin Diseases Antibodies  >34 publications with IL1A and Skin Diseases
 Lung Neoplasms Antibodies  >9 publications with IL1A and Lung Neoplasms
 Pain Antibodies  >9 publications with IL1A and Pain
 Fibrosis Antibodies  >9 publications with IL1A and Fibrosis
 Heart Diseases Antibodies  >9 publications with IL1A and Heart Diseases
 Kidney Diseases Antibodies  >8 publications with IL1A and Kidney Diseases
 Liver Diseases Antibodies  >7 publications with IL1A and Liver Diseases
 Hypertension Antibodies  >6 publications with IL1A and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >77 publications with IL1A and Blood
 Skin Antibodies  >24 publications with IL1A and Skin
 Bone Marrow Antibodies  >7 publications with IL1A and Bone Marrow
 Spleen Antibodies  >2 publications with IL1A and Spleen
 Mammary Gland Antibodies  >1 publications with IL1A and Mammary Gland
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