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IL9 sirna

Scan QR to view Datasheet Catalog #    MBS8235064 IL9 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL9, siRNA

 Also Known As   

IL9 siRNA (Human)

 Product Synonym Names    Interleukin-9; IL-9; Cytokine P40; T-cell growth factor P40
 Product Gene Name   

IL9 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146931
 3D Structure    ModBase 3D Structure for P15248
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    IL9 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human IL9 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of IL9 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for IL9 sirna

   siRNA to inhibit IL9 expression using RNA interference
 Applications Tested/Suitable for IL9 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for IL9. It may not necessarily be applicable to this product.
 NCBI GI #    10834980
 NCBI GeneID    3578
 NCBI Accession #    NP_000581.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000590.1 [Other Products]
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 UniProt Primary Accession #    P15248 [Other Products]
 UniProt Related Accession #    P15248 [Other Products]
 Molecular Weight    15,909 Da
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 NCBI Official Full Name    interleukin-9
 NCBI Official Synonym Full Names    interleukin 9
 NCBI Official Symbol    IL9 [Similar Products]
 NCBI Official Synonym Symbols   
P40; HP40; IL-9
[Similar Products]
 NCBI Protein Information    interleukin-9
 UniProt Protein Name    Interleukin-9
 UniProt Synonym Protein Names   
Cytokine P40; T-cell growth factor P40
 Protein Family    Interleukin
 UniProt Gene Name    IL9 [Similar Products]
 UniProt Synonym Gene Names    IL-9 [Similar Products]
 UniProt Entry Name    IL9_HUMAN
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 NCBI Summary for IL9    The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL9    IL9: Supports IL-2 independent and IL-4 independent growth of helper T-cells. Belongs to the IL-7/IL-9 family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; interleukin-9 receptor binding; cytokine activity

Biological Process: positive regulation of cell proliferation; immune response; inflammatory response; positive regulation of cell growth; positive regulation of interleukin-5 biosynthetic process
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 Research Articles on IL9    1. The results provide evidence that IL-9 is predominantly involved in the pathogenesis of ulcerative colitis suggesting that targeting IL-9 might become a therapeutic option for patients with UC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL9 sirnaPathways associated with IL9 sirna
 Reference Product  PubMed Publications
 IL4 sirna  >42 publications with IL9 and IL4
 IL13 sirna  >27 publications with IL9 and IL13
 IL5 sirna  >26 publications with IL9 and IL5
 IL2 sirna  >16 publications with IL9 and IL2
 IL3 sirna  >12 publications with IL9 and IL3
 IL9R sirna  >7 publications with IL9 and IL9R
 IL4R sirna  >6 publications with IL9 and IL4R
 CCL11 sirna  >2 publications with IL9 and CCL11
 MUC5AC sirna  >2 publications with IL9 and MUC5AC
 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-9 Signaling Pathway antibodies  IL-9 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 TCR Signaling Pathway antibodies  TCR Signaling Pathway Diagram
Diseases associated with IL9 sirnaOrgans/Tissues associated with IL9 sirna
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >61 publications with IL9 and Immune System Diseases
 Hypersensitivity Antibodies  >41 publications with IL9 and Hypersensitivity
 Inflammation Antibodies  >32 publications with IL9 and Inflammation
 Lung Diseases Antibodies  >31 publications with IL9 and Lung Diseases
 Necrosis Antibodies  >17 publications with IL9 and Necrosis
 Chromosome Aberrations Antibodies  >4 publications with IL9 and Chromosome Aberrations
 Liver Diseases Antibodies  >3 publications with IL9 and Liver Diseases
 Heart Diseases Antibodies  >3 publications with IL9 and Heart Diseases
 Hyperplasia Antibodies  >3 publications with IL9 and Hyperplasia
 Atherosclerosis Antibodies  >2 publications with IL9 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with IL9 and Kidney
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