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ITGAE sirna

Scan QR to view Datasheet Catalog #    MBS8234393 ITGAE sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

ITGAE siRNA (Human)

 Product Synonym Names    Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD antigen CD103
 Product Gene Name   

ITGAE sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604682
 3D Structure    ModBase 3D Structure for P38570
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    ITGAE siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human ITGAE gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of ITGAE sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ITGAE sirna

   siRNA to inhibit ITGAE expression using RNA interference
 Applications Tested/Suitable for ITGAE sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ITGAE. It may not necessarily be applicable to this product.
 NCBI GI #    148728188
 NCBI GeneID    3682
 NCBI Accession #    NP_002199.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002208.4 [Other Products]
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 UniProt Primary Accession #    P38570 [Other Products]
 UniProt Secondary Accession #    Q17RS6; Q9NZU9 [Other Products]
 UniProt Related Accession #    P38570 [Other Products]
 Molecular Weight    130,159 Da
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 NCBI Official Full Name    integrin alpha-E
 NCBI Official Synonym Full Names    integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
 NCBI Official Symbol    ITGAE [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    integrin alpha-E
 UniProt Protein Name    Integrin alpha-E
 UniProt Synonym Protein Names   
HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; CD_antigen: CD103
 Protein Family    Integrin
 UniProt Gene Name    ITGAE [Similar Products]
 UniProt Entry Name    ITAE_HUMAN
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 NCBI Summary for ITGAE    Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ITGAE    ITGAE: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Belongs to the integrin alpha chain family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: plasma membrane; integrin complex; external side of plasma membrane

Molecular Function: metal ion binding

Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; cell adhesion
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 Research Articles on ITGAE    1. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ITGAE sirnaPathways associated with ITGAE sirna
 Reference Product  PubMed Publications
 IL2 sirna  >1 publications with ITGAE and IL2
 FOXP3 sirna  >1 publications with ITGAE and FOXP3
 TGFB1 sirna  >1 publications with ITGAE and TGFB1
 ITGB7 sirna  >1 publications with ITGAE and ITGB7
 Products by Pathway  Pathway Diagram
 E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies  E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
Diseases associated with ITGAE sirnaOrgans/Tissues associated with ITGAE sirna
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >3 publications with ITGAE and Lung Diseases
 Inflammation Antibodies  >3 publications with ITGAE and Inflammation
 Skin Diseases Antibodies  >2 publications with ITGAE and Skin Diseases
 Vascular Diseases Antibodies  >1 publications with ITGAE and Vascular Diseases
 Heart Diseases Antibodies  >1 publications with ITGAE and Heart Diseases
 Pneumonia Antibodies  >1 publications with ITGAE and Pneumonia
 Fibrosis Antibodies  >1 publications with ITGAE and Fibrosis
 Neoplasms, Experimental Antibodies  >1 publications with ITGAE and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with ITGAE and Blood
 Lung Antibodies  >4 publications with ITGAE and Lung
 Uterus Antibodies  >2 publications with ITGAE and Uterus
 Vascular Antibodies  >2 publications with ITGAE and Vascular
 Skin Antibodies  >2 publications with ITGAE and Skin
 Embryonic Tissue Antibodies  >1 publications with ITGAE and Embryonic Tissue
 Heart Antibodies  >1 publications with ITGAE and Heart
 Lymph Antibodies  >1 publications with ITGAE and Lymph
 Intestine Antibodies  >1 publications with ITGAE and Intestine
 Kidney Antibodies  >1 publications with ITGAE and Kidney
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