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ITGB4 sirna

Scan QR to view Datasheet Catalog #    MBS8238727 ITGB4 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ITGB4, siRNA

 Also Known As   

ITGB4 siRNA (Mouse)

 Product Synonym Names    Integrin beta-4; CD antigen CD104
 Product Gene Name   

ITGB4 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for A2A863
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    ITGB4 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse ITGB4 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of ITGB4 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ITGB4 sirna

   siRNA to inhibit ITGB4 expression using RNA interference
 Applications Tested/Suitable for ITGB4 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ITGB4. It may not necessarily be applicable to this product.
 NCBI GI #    568972376
 NCBI GeneID    192897
 NCBI Accession #    XP_006532635.1 [Other Products]
 NCBI GenBank Nucleotide #    XM_006532572.2 [Other Products]
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 UniProt Primary Accession #    A2A863 [Other Products]
 UniProt Secondary Accession #    Q6PCS0; Q8R3J1; Q91W15; A2A865; A2A866 [Other Products]
 UniProt Related Accession #    A2A863 [Other Products]
 Molecular Weight    200,261 Da
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 NCBI Official Full Name    integrin beta-4 isoform X6
 NCBI Official Synonym Full Names    integrin beta 4
 NCBI Official Symbol    Itgb4 [Similar Products]
 NCBI Official Synonym Symbols   
CD104; AA407042; C230078O20
[Similar Products]
 NCBI Protein Information    integrin beta-4
 UniProt Protein Name    Integrin beta-4
 UniProt Synonym Protein Names   
CD_antigen: CD104
 Protein Family    Integrin
 UniProt Gene Name    Itgb4 [Similar Products]
 UniProt Entry Name    ITB4_MOUSE
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 NCBI Summary for ITGB4    Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ITGB4    ITGB4 iso2: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.; Cell adhesion

Cellular Component: cell surface; leading edge; integral to membrane; cell cortex; hemidesmosome; membrane; cytoplasm; basal plasma membrane; plasma membrane; basement membrane; integrin complex; cell junction; receptor complex

Molecular Function: G-protein-coupled receptor binding; receptor activity

Biological Process: integrin-mediated signaling pathway; skin development; hemidesmosome assembly; filopodium formation; gut development; multicellular organismal development; cell-matrix adhesion; cell motility involved in cell locomotion; response to wounding; autophagy; cell communication; cell adhesion
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 Research Articles on ITGB4    1. keratins have a role in controlling beta4-integrin endocytosis involving a plectin-Erk1/2-dependent mechanism relevant for epidermal differentiation and pathogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ITGB4 sirnaDiseases associated with ITGB4 sirna
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Epidermolysis Bullosa Antibodies  >85 publications with ITGB4 and Epidermolysis Bullosa
 Breast Neoplasms Antibodies  >63 publications with ITGB4 and Breast Neoplasms
 Adenocarcinoma Antibodies  >61 publications with ITGB4 and Adenocarcinoma
 Epidermolysis Bullosa, Junctional Antibodies  >56 publications with ITGB4 and Epidermolysis Bullosa, Junctional
 Pyloric Atresia Antibodies  >44 publications with ITGB4 and Pyloric Atresia
 Inflammation Antibodies  >34 publications with ITGB4 and Inflammation
 Lung Diseases Antibodies  >34 publications with ITGB4 and Lung Diseases
 Lung Neoplasms Antibodies  >33 publications with ITGB4 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >31 publications with ITGB4 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >26 publications with ITGB4 and Disease Models, Animal
Organs/Tissues associated with ITGB4 sirna
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >158 publications with ITGB4 and Skin
 Eye Antibodies  >67 publications with ITGB4 and Eye
 Lung Antibodies  >63 publications with ITGB4 and Lung
 Embryonic Tissue Antibodies  >48 publications with ITGB4 and Embryonic Tissue
 Brain Antibodies  >27 publications with ITGB4 and Brain
 Intestine Antibodies  >24 publications with ITGB4 and Intestine
 Mammary Gland Antibodies  >15 publications with ITGB4 and Mammary Gland
 Uterus Antibodies  >10 publications with ITGB4 and Uterus
 Tongue Antibodies  >8 publications with ITGB4 and Tongue
 Salivary Gland Antibodies  >7 publications with ITGB4 and Salivary Gland
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