NP_001102510.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
180,550 Da
NCBI Official Full Name
kinesin-like protein KIF21A isoform 1
NCBI Official Synonym Full Names
kinesin family member 21A
NCBI Protein Information
kinesin-like protein KIF21A
UniProt Protein Name
Kinesin-like protein KIF21A
UniProt Synonym Gene Names
UniProt Entry Name
KI21A_MOUSE
UniProt Comments for KIF21A
KIF21A: Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Defects in KIF21A are a cause of congenital fibrosis of extraocular muscles type 1 (CFEOM1). CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM1 individuals show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. Belongs to the kinesin-like protein family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motor; Microtubule-binding
Cellular Component: kinesin complex; microtubule; cell projection; cytoskeleton; cytoplasm
Molecular Function: microtubule binding; ATPase activity; nucleotide binding; microtubule motor activity; ATP binding
Biological Process: microtubule-based movement
Research Articles on KIF21A
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Products associated with KIF21A sirna
Diseases associated with KIF21A sirna
Organs/Tissues associated with KIF21A sirna
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