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KLHL20 sirna

Scan QR to view Datasheet Catalog #    MBS8241052 KLHL20 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

KLHL20 siRNA (Mouse)

 Product Synonym Names    KIAA4210; KLEIP; Kelch-like protein 20; Kelch-like ECT2-interacting protein
 Product Gene Name   

KLHL20 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8VCK5
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    KLHL20 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse KLHL20 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of KLHL20 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KLHL20 sirna

   siRNA to inhibit KLHL20 expression using RNA interference
 Applications Tested/Suitable for KLHL20 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for KLHL20. It may not necessarily be applicable to this product.
 NCBI GI #    87116679
 NCBI GeneID    226541
 NCBI Accession #    NP_001034571.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001039482.1 [Other Products]
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 UniProt Primary Accession #    Q8VCK5 [Other Products]
 UniProt Secondary Accession #    Q5DTH3; Q8BWA2 [Other Products]
 UniProt Related Accession #    Q8VCK5 [Other Products]
 Molecular Weight    67,412 Da
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 NCBI Official Full Name    kelch-like protein 20
 NCBI Official Synonym Full Names    kelch-like 20
 NCBI Official Symbol    Klhl20 [Similar Products]
 NCBI Official Synonym Symbols   
Kleip; AI504637; mKIAA4210; D930050H05Rik
[Similar Products]
 NCBI Protein Information    kelch-like protein 20
 UniProt Protein Name    Kelch-like protein 20
 UniProt Synonym Protein Names   
Kelch-like ECT2-interacting protein
 Protein Family    Kelch-like protein
 UniProt Gene Name    Klhl20 [Similar Products]
 UniProt Synonym Gene Names    Kiaa4210; Kleip [Similar Products]
 UniProt Entry Name    KLH20_MOUSE
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 UniProt Comments for KLHL20    KLHL20: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases.

Cellular Component: Golgi apparatus; PML body; cell projection; cytoplasm; trans-Golgi network; nucleus

Molecular Function: interferon-gamma binding; ubiquitin-protein ligase activity; actin binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein transport; transport; Golgi to endosome transport; protein ubiquitination; negative regulation of apoptosis
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 Research Articles on KLHL20    1. KLEIP is an important molecule regulating corneal epithelial integrity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KLHL20 sirnaPathways associated with KLHL20 sirna
 Reference Product  PubMed Publications
 Cul3 sirna  >7 publications with KLHL20 and Cul3
 Rbx1 sirna  >1 publications with KLHL20 and Rbx1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with KLHL20 sirnaOrgans/Tissues associated with KLHL20 sirna
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >2 publications with KLHL20 and Prostatic Neoplasms
 Disease Models, Animal Antibodies  >2 publications with KLHL20 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with KLHL20 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >2 publications with KLHL20 and Prostate
 Brain Antibodies  >2 publications with KLHL20 and Brain
 Kidney Antibodies  >1 publications with KLHL20 and Kidney
 Lung Antibodies  >1 publications with KLHL20 and Lung
 Skin Antibodies  >1 publications with KLHL20 and Skin
 Blood Antibodies  >1 publications with KLHL20 and Blood
 Eye Antibodies  >1 publications with KLHL20 and Eye
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