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KYNU sirna

Scan QR to view Datasheet Catalog #    MBS8210758 KYNU sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KYNU, siRNA

★Popular Item★
 Also Known As   

KYNU siRNA (Rat)

 Product Synonym Names    Kynureninase; L-kynurenine hydrolase
 Product Gene Name   

KYNU sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P70712
 Host    Synthetic
 Species Reactivity    Rat
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 Specificity    KYNU siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat KYNU gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of KYNU sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KYNU sirna

   siRNA to inhibit KYNU expression using RNA interference
 Applications Tested/Suitable for KYNU sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for KYNU. It may not necessarily be applicable to this product.
 NCBI GI #    16758776
 NCBI GeneID    116682
 NCBI Accession #    NP_446354.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053902.2 [Other Products]
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 UniProt Primary Accession #    P70712 [Other Products]
 UniProt Secondary Accession #    Q68G25; Q7M0D0; Q9QW90 [Other Products]
 UniProt Related Accession #    P70712 [Other Products]
 Molecular Weight    52,470 Da
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 NCBI Official Full Name    kynureninase
 NCBI Official Synonym Full Names    kynureninase
 NCBI Official Symbol    Kynu [Similar Products]
 NCBI Protein Information    kynureninase
 UniProt Protein Name    Kynureninase
 UniProt Synonym Protein Names   
L-kynurenine hydrolase
 Protein Family    Kynureninase
 UniProt Gene Name    Kynu [Similar Products]
 UniProt Entry Name    KYNU_RAT
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 NCBI Summary for KYNU    enzyme involved in the biosynthesis of NAD cofactors from tryptophan [RGD, Feb 2006]
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 UniProt Comments for KYNU    KYNU: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Belongs to the kynureninase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Hydrolase; Amino Acid Metabolism - tryptophan; EC 3.7.1.3

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol

Molecular Function: protein homodimerization activity; kynureninase activity; pyridoxal phosphate binding

Biological Process: anthranilate metabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; tryptophan catabolic process
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 Research Articles on KYNU    1. Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KYNU sirnaPathways associated with KYNU sirna
 Reference Product  PubMed Publications
 Ido1 sirna  >2 publications with KYNU and Ido1
 Kmo sirna  >2 publications with KYNU and Kmo
 Aadat sirna  >1 publications with KYNU and Aadat
 Ccbl1 sirna  >1 publications with KYNU and Ccbl1
 Products by Pathway  Pathway Diagram
 L-tryptophan Degradation III (eukaryotic) Pathway antibodies  L-tryptophan Degradation III (eukaryotic) Pathway Diagram
 L-tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway antibodies  L-tryptophan Degradation XI (mammalian, Via Kynurenine) Pathway Diagram
 L-tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway antibodies  L-tryptophan Degradation To 2-amino-3-carboxymuconate Semialdehyde Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tryptophan Catabolism Pathway antibodies  Tryptophan Catabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
Diseases associated with KYNU sirnaOrgans/Tissues associated with KYNU sirna
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with KYNU and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >3 publications with KYNU and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >1 publications with KYNU and Congenital Abnormalities
 Brain Diseases Antibodies  >1 publications with KYNU and Brain Diseases
 Neurobehavioral Manifestations Antibodies  >1 publications with KYNU and Neurobehavioral Manifestations
 Necrosis Antibodies  >1 publications with KYNU and Necrosis
 Hydroxykynureninuria Antibodies  >1 publications with KYNU and Hydroxykynureninuria
 Neurodegenerative Diseases Antibodies  >1 publications with KYNU and Neurodegenerative Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with KYNU and Liver
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