NP_034810.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
190,610 Da
NCBI Official Full Name
laminin subunit alpha-3
NCBI Official Synonym Full Names
laminin, alpha 3
NCBI Protein Information
laminin subunit alpha-3
UniProt Protein Name
Laminin subunit alpha-3
UniProt Synonym Protein Names
Epiligrin subunit alpha; Kalinin subunit alpha; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; Nicein subunit alpha
UniProt Entry Name
LAMA3_MOUSE
UniProt Comments for LAMA3
LAMA3: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Defects in LAMA3 are a cause of epidermolysis bullosa junctional Herlitz type (H-JEB); also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB defines a group of blistering skin diseases characterized by tissue separation which occurs within the dermo-epidermal basement membrane. H-JEB is a severe, infantile and lethal form. Death occurs usually within the first six months of life. Occasionally, children survive to teens. H-JEB is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Defects in LAMA3 are the cause of laryngoonychocutaneous syndrome (LOCS). LOCS is an autosomal recessive epithelial disorder confined to the Punjabi Muslim population. The condition is characterized by cutaneous erosions, nail dystrophy and exuberant vascular granulation tissue in certain epithelia, especially conjunctiva and larynx. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Cellular Component: proteinaceous extracellular matrix; laminin-5 complex; laminin-3 complex; laminin-1 complex; cell-cell adherens junction; hemidesmosome; extracellular region; basement membrane
Molecular Function: receptor binding
Biological Process: regulation of cell adhesion; cell-cell adhesion; hemidesmosome assembly; regulation of embryonic development; cell adhesion; regulation of cell migration
Research Articles on LAMA3
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Products associated with LAMA3 sirna
Pathways associated with LAMA3 sirna
Diseases associated with LAMA3 sirna
Organs/Tissues associated with LAMA3 sirna
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