NP_034855.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,102 Da
NCBI Official Full Name
LIM homeobox transcription factor 1-beta
NCBI Official Synonym Full Names
LIM homeobox transcription factor 1 beta
NCBI Protein Information
LIM homeobox transcription factor 1-beta
UniProt Protein Name
LIM homeobox transcription factor 1-beta
UniProt Synonym Protein Names
LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B
UniProt Synonym Gene Names
UniProt Entry Name
LMX1B_MOUSE
UniProt Comments for LMX1B
LMX1B: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Defects in LMX1B are the cause of nail-patella syndrome (NPS); also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding; Cell development/differentiation
Cellular Component: nucleus
Molecular Function: DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding; transcription factor activity
Biological Process: camera-type eye development; collagen fibril organization; transcription, DNA-dependent; multicellular organismal development; neuron migration; cerebellum morphogenesis; limb morphogenesis; regulation of transcription from RNA polymerase II promoter; neuron differentiation; cell proliferation; organ growth; regulation of transcription, DNA-dependent; regulation of gene expression; midbrain development; positive regulation of transcription from RNA polymerase II promoter; embryonic limb morphogenesis; central nervous system neuron development
Research Articles on LMX1B
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Pathways associated with LMX1B sirna
Diseases associated with LMX1B sirna
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