NP_001257473.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
48,107 Da
NCBI Official Full Name
mitogen-activated protein kinase 9 isoform 2
NCBI Official Synonym Full Names
mitogen-activated protein kinase 9
NCBI Official Synonym Symbols
NCBI Protein Information
mitogen-activated protein kinase 9
UniProt Protein Name
Mitogen-activated protein kinase 9
UniProt Synonym Protein Names
SAPK-alpha; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2; p54-alpha
UniProt Synonym Gene Names
UniProt Entry Name
MK09_RAT
NCBI Summary for MAPK9
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, apoptosis, inflammation and transformation. For example, this kinase plays a dominant role in mediating proliferation of lung cancer and prostate cancer cells, and in regulation of osmotic stress-induced tight junction disruption. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2012]
UniProt Comments for MAPK9
JNK2: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses including UV radiation. Phosphorylates specific transcription factors such as c-Jun and ATF2, mediating immediate-early gene expression. Closely related to JNK1. Both are involved in UV radiation induced apoptosis. Blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells in the mouse. Four alternatively-spliced isoforms have been described.
Protein type: Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.24; CMGC group; MAPK family; MAPK/JNK subfamily; JNK subfamily
Cellular Component: mitochondrion; cytoplasm; cytosol; nucleus
Molecular Function: MAP kinase activity; protein binding; mitogen-activated protein kinase kinase kinase binding; caspase activator activity; JUN kinase activity; transcription factor binding; ATP binding
Biological Process: central nervous system development; positive regulation of nitric oxide biosynthetic process; regulation of protein ubiquitination; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; response to toxin; rhythmic process; positive regulation of caspase activity; regulation of JNK cascade; protein amino acid phosphorylation; response to organic substance; JNK cascade; protein targeting to mitochondrion; neurite development; positive regulation of prostaglandin biosynthetic process; caspase activation; response to drug; release of cytochrome c from mitochondria; MAPKKK cascade; regulation of circadian rhythm; positive regulation of chemokine production; JUN phosphorylation; response to cadmium ion; response to mechanical stimulus; positive regulation of prostaglandin secretion; positive regulation of protein amino acid phosphorylation; positive regulation of nitric-oxide synthase biosynthetic process; response to amine stimulus
Research Articles on MAPK9
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Products associated with MAPK9 sirna
Pathways associated with MAPK9 sirna
Diseases associated with MAPK9 sirna
Organs/Tissues associated with MAPK9 sirna
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