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MLNR sirna

Scan QR to view Datasheet Catalog #    MBS8211084 MLNR sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MLNR, siRNA

 Also Known As   

MLNR siRNA (Human)

 Product Synonym Names    GPR38; MTLR; MTLR1; Motilin receptor; G-protein coupled receptor 38
 Product Gene Name   

MLNR sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602885
 3D Structure    ModBase 3D Structure for O43193
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    MLNR siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human MLNR gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of MLNR sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MLNR sirna

   siRNA to inhibit MLNR expression using RNA interference
 Applications Tested/Suitable for MLNR sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for MLNR. It may not necessarily be applicable to this product.
 NCBI GI #    4504095
 NCBI GeneID    2862
 NCBI Accession #    NP_001498.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001507.1 [Other Products]
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 UniProt Primary Accession #    O43193 [Other Products]
 UniProt Related Accession #    O43193 [Other Products]
 Molecular Weight    42,026 Da
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 NCBI Official Full Name    motilin receptor
 NCBI Official Synonym Full Names    motilin receptor
 NCBI Official Symbol    MLNR [Similar Products]
 NCBI Official Synonym Symbols   
GPR38; MTLR1
[Similar Products]
 NCBI Protein Information    motilin receptor
 UniProt Protein Name    Motilin receptor
 UniProt Synonym Protein Names   
G-protein coupled receptor 38
 Protein Family    Motilin receptor
 UniProt Gene Name    MLNR [Similar Products]
 UniProt Synonym Gene Names    GPR38; MTLR; MTLR1 [Similar Products]
 UniProt Entry Name    MTLR_HUMAN
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 NCBI Summary for MLNR    Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
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 UniProt Comments for MLNR    MLNR: Receptor for motilin. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; growth hormone-releasing hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; digestion
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 Research Articles on MLNR    1. data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MLNR sirnaPathways associated with MLNR sirna
 Reference Product  PubMed Publications
 MLN sirna  >3 publications with MLNR and MLN
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with MLNR sirna
 Disease Name  Pubmed Publications
 Cholecystitis Antibodies  >1 publications with MLNR and Cholecystitis
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