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MTO1 sirna

Scan QR to view Datasheet Catalog #    MBS8240179 MTO1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

MTO1 siRNA (Mouse)

 Product Synonym Names    Protein MTO1 homolog mitochondrial
 Product Gene Name   

MTO1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q923Z3
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    MTO1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse MTO1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of MTO1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MTO1 sirna

   siRNA to inhibit MTO1 expression using RNA interference
 Applications Tested/Suitable for MTO1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for MTO1. It may not necessarily be applicable to this product.
 NCBI GI #    171460946
 NCBI GeneID    68291
 NCBI Accession #    NP_080934.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_026658.2 [Other Products]
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 UniProt Primary Accession #    Q923Z3 [Other Products]
 UniProt Secondary Accession #    Q9D2Q5 [Other Products]
 UniProt Related Accession #    Q923Z3 [Other Products]
 Molecular Weight    74,332 Da
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 NCBI Official Full Name    protein MTO1 homolog, mitochondrial
 NCBI Official Synonym Full Names    mitochondrial translation optimization 1 homolog (S. cerevisiae)
 NCBI Official Symbol    Mto1 [Similar Products]
 NCBI Official Synonym Symbols   
2310039H01Rik; 5730419A02Rik
[Similar Products]
 NCBI Protein Information    protein MTO1 homolog, mitochondrial
 UniProt Protein Name    Protein MTO1 homolog, mitochondrial
 Protein Family    Mitochondrial translation optimization protein
 UniProt Gene Name    Mto1 [Similar Products]
 UniProt Entry Name    MTO1_MOUSE
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 UniProt Comments for MTO1    MTO1: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Defects in MTO1 are the cause of combined oxidative phosphorylation deficiency type 10 (COXPD10). An autosomal recessive disorder resulting in variable defects of mitochondrial oxidative respiration. Affected individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. The severity is variable, but can be fatal in the most severe cases. Belongs to the MnmG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing

Cellular Component: mitochondrion

Molecular Function: FAD binding

Biological Process: tRNA wobble uridine modification; tRNA processing
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 Research Articles on MTO1    1. These observations suggest that the mouse MTO1 is a structural and functional homolog of yeast MTO1, thereby playing a role in the mitochondrial tRNA modification and protein synthesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MTO1 sirnaDiseases associated with MTO1 sirna
 Reference Product  PubMed Publications
 Trmu sirna  >8 publications with MTO1 and Trmu
 Gtpbp3 sirna  >5 publications with MTO1 and Gtpbp3
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >5 publications with MTO1 and Cardiovascular Diseases
 Atrophy Antibodies  >1 publications with MTO1 and Atrophy
Organs/Tissues associated with MTO1 sirna
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >5 publications with MTO1 and Muscle
 Brain Antibodies  >3 publications with MTO1 and Brain
 Heart Antibodies  >2 publications with MTO1 and Heart
 Blood Antibodies  >1 publications with MTO1 and Blood
 Liver Antibodies  >1 publications with MTO1 and Liver
 Eye Antibodies  >1 publications with MTO1 and Eye
 Mammary Gland Antibodies  >1 publications with MTO1 and Mammary Gland
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