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MUM1 sirna

Scan QR to view Datasheet Catalog #    MBS8232301 MUM1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MUM1, siRNA

 Also Known As   

MUM1 siRNA (Human)

 Product Synonym Names    EXPAND1; PWWP domain-containing protein MUM1; Mutated melanoma-associated antigen 1; MUM-1; Protein expandere
 Product Gene Name   

MUM1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q2TAK8
 Host    Synthetic
 Species Reactivity    Human
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 Specificity    MUM1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human MUM1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of MUM1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MUM1 sirna

   siRNA to inhibit MUM1 expression using RNA interference
 Applications Tested/Suitable for MUM1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for MUM1. It may not necessarily be applicable to this product.
 NCBI GI #    31652259
 NCBI GeneID    84939
 NCBI Accession #    NP_116242.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032853.3 [Other Products]
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 UniProt Primary Accession #    Q2TAK8 [Other Products]
 UniProt Secondary Accession #    Q13109; Q5XKB9; Q8N2I4; Q96A67; A1L489; B5ME02; B7ZLY8; J3KQD6 [Other Products]
 UniProt Related Accession #    Q2TAK8 [Other Products]
 Molecular Weight    80,700 Da
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 NCBI Official Full Name    PWWP domain-containing protein MUM1
 NCBI Official Synonym Full Names    melanoma associated antigen (mutated) 1
 NCBI Official Symbol    MUM1 [Similar Products]
 NCBI Official Synonym Symbols   
MUM-1; EXPAND1; HSPC211
[Similar Products]
 NCBI Protein Information    PWWP domain-containing protein MUM1
 UniProt Protein Name    PWWP domain-containing protein MUM1
 UniProt Synonym Protein Names   
Mutated melanoma-associated antigen 1; MUM-1; Protein expandere
 Protein Family    PWWP domain-containing protein
 UniProt Gene Name    MUM1 [Similar Products]
 UniProt Synonym Gene Names    EXPAND1; MUM-1 [Similar Products]
 UniProt Entry Name    MUM1_HUMAN
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 UniProt Comments for MUM1    MUM1: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. Belongs to the MUM1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleus

Molecular Function: protein binding; nucleosome binding

Biological Process: establishment and/or maintenance of chromatin architecture; DNA repair
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 Research Articles on MUM1    1. These results show that MUM1 is a strong and robust predictive immunohistochemical marker in patients with follicular lymphoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MUM1 sirnaDiseases associated with MUM1 sirna
 Reference Product  PubMed Publications
 CXCR4 sirna  >1 publications with MUM1 and CXCR4
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >32 publications with MUM1 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >23 publications with MUM1 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >14 publications with MUM1 and Cell Transformation, Neoplastic
 Hyperplasia Antibodies  >8 publications with MUM1 and Hyperplasia
 Necrosis Antibodies  >7 publications with MUM1 and Necrosis
 Inflammation Antibodies  >6 publications with MUM1 and Inflammation
 Liver Neoplasms Antibodies  >5 publications with MUM1 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >5 publications with MUM1 and Neoplasm Metastasis
 Liver Diseases Antibodies  >4 publications with MUM1 and Liver Diseases
 Ovarian Neoplasms Antibodies  >4 publications with MUM1 and Ovarian Neoplasms
Organs/Tissues associated with MUM1 sirna
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >124 publications with MUM1 and Blood
 Lymph Node Antibodies  >111 publications with MUM1 and Lymph Node
 Lymph Antibodies  >50 publications with MUM1 and Lymph
 Bone Antibodies  >35 publications with MUM1 and Bone
 Skin Antibodies  >31 publications with MUM1 and Skin
 Bone Marrow Antibodies  >30 publications with MUM1 and Bone Marrow
 Stomach Antibodies  >14 publications with MUM1 and Stomach
 Liver Antibodies  >11 publications with MUM1 and Liver
 Intestine Antibodies  >11 publications with MUM1 and Intestine
 Vascular Antibodies  >10 publications with MUM1 and Vascular
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