NP_002477.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,839 Da
NCBI Official Full Name
nuclear cap-binding protein subunit 1
NCBI Official Synonym Full Names
nuclear cap binding protein subunit 1, 80kDa
NCBI Protein Information
nuclear cap-binding protein subunit 1
UniProt Protein Name
Nuclear cap-binding protein subunit 1
UniProt Synonym Protein Names
80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit
UniProt Synonym Gene Names
UniProt Entry Name
NCBP1_HUMAN
NCBI Summary for NCBP1
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]
UniProt Comments for NCBP1
NCBP1: mediates U snRNA export from the nucleus. Binds to 5' capped mRNA. Found in aU snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX. Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2.
Protein type: Translation; RNA processing; Spliceosome
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: nucleoplasm; mRNA cap complex; mitochondrion; cytoplasm; ribonucleoprotein complex; nucleus; cytosol
Molecular Function: protein binding; RNA binding; RNA cap binding
Biological Process: transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis; viral reproduction; positive regulation of viral transcription; RNA splicing; positive regulation of mRNA 3'-end processing; histone mRNA metabolic process; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA capping; RNA elongation from RNA polymerase II promoter; mRNA catabolic process, nonsense-mediated decay; gene expression; RNA-mediated gene silencing; nuclear mRNA cis splicing, via U2-type spliceosome; mRNA 3'-end processing; termination of RNA polymerase II transcription; regulation of translational initiation; mRNA cleavage
Research Articles on NCBP1
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Products associated with NCBP1 sirna
Pathways associated with NCBP1 sirna
Organs/Tissues associated with NCBP1 sirna
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