NP_001139670.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
38,570 Da
NCBI Official Full Name
homeobox protein Nkx-2.1
NCBI Official Synonym Full Names
NK2 homeobox 1
NCBI Official Synonym Symbols
T/EBP; Titf1; Ttf-1; Nkx2.1; AV026640 [Similar Products]
NCBI Protein Information
homeobox protein Nkx-2.1
UniProt Protein Name
Homeobox protein Nkx-2.1
UniProt Synonym Protein Names
Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1; Thyroid-specific enhancer-binding protein; T/EBP
UniProt Synonym Gene Names
UniProt Entry Name
NKX21_MOUSE
UniProt Comments for NKX2-1
NKX2-1: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC); also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances. Defects in NKX2-1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD). This syndrome include neurological, thyroid, and respiratory problems. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; axon guidance; positive regulation of transcription, DNA-dependent; rhythmic process; neuron migration; globus pallidus development; response to lipopolysaccharide; locomotory behavior; forebrain dorsal/ventral pattern formation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of circadian rhythm; forebrain neuron differentiation; cerebral cortex neuron differentiation; Leydig cell differentiation; hyperosmotic salinity response; regulation of transcription, DNA-dependent; phospholipid metabolic process; renin-angiotensin regulation of blood volume; thyroid gland development; oligodendrocyte differentiation; anatomical structure formation; feeding behavior; forebrain neuron fate commitment; negative regulation of cell migration; transcription, DNA-dependent; hippocampus development; induction; neuron fate commitment; cerebral cortex GABAergic interneuron differentiation; pattern specification process; menarche; regulation of transcription from RNA polymerase II promoter; telencephalon development; organ morphogenesis; cerebral cortex cell migration; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; lung development; endoderm development; telencephalon cell migration
Research Articles on NKX2-1
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Products associated with NKX2-1 sirna
Diseases associated with NKX2-1 sirna
Organs/Tissues associated with NKX2-1 sirna
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