NP_001156640.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,971 Da
NCBI Official Full Name
BDNF/NT-3 growth factors receptor isoform 2
NCBI Official Synonym Full Names
neurotrophic tyrosine kinase, receptor, type 2
NCBI Official Synonym Symbols
Tkrb; trkB; TRKB1; trk-B; RATTRKB1 [Similar Products]
NCBI Protein Information
BDNF/NT-3 growth factors receptor
UniProt Protein Name
BDNF/NT-3 growth factors receptor
UniProt Synonym Protein Names
Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Trk-B
UniProt Synonym Gene Names
UniProt Entry Name
NTRK2_RAT
NCBI Summary for NTRK2
receptor for brain-derived neurotrophic factor (BDNF) [RGD, Feb 2006]
UniProt Comments for NTRK2
TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; Kinase, protein; TK group; Trk family
Cellular Component: cell surface; rough endoplasmic reticulum; cell; integral to plasma membrane; postsynaptic density; dendrite; dendritic spine; terminal button; excitatory synapse; perikaryon; cytosol; Golgi membrane; postsynaptic membrane; growth cone; cell soma; axon; cytoplasm; presynaptic active zone; plasma membrane; endosome membrane; intracellular; nerve terminal; endosome; receptor complex
Molecular Function: brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding
Biological Process: circadian rhythm; mechanoreceptor differentiation; retinal rod cell development; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; regulation of dendrite development; neuron migration; regulation of neurotransmitter secretion; positive regulation of synaptic transmission, glutamatergic; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; inflammatory response; vasculogenesis; neuromuscular junction development; central nervous system neuron development; aging; response to light stimulus; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; peripheral nervous system neuron development; long-term memory; glutamate secretion; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development
Research Articles on NTRK2
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Products associated with NTRK2 sirna
Pathways associated with NTRK2 sirna
Diseases associated with NTRK2 sirna
Organs/Tissues associated with NTRK2 sirna
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