NP_620781.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
25,228 Da
NCBI Official Full Name
ornithine decarboxylase antizyme 1 isoform 1
NCBI Official Synonym Full Names
ornithine decarboxylase antizyme 1
NCBI Protein Information
ornithine decarboxylase antizyme 1
UniProt Protein Name
Ornithine decarboxylase antizyme 1
UniProt Synonym Gene Names
UniProt Entry Name
OAZ1_RAT
NCBI Summary for OAZ1
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for OAZ1
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol ().
Research Articles on OAZ1
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Products associated with OAZ1 sirna
Pathways associated with OAZ1 sirna
Diseases associated with OAZ1 sirna
Organs/Tissues associated with OAZ1 sirna
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