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ORC6 sirna

Scan QR to view Datasheet Catalog #    MBS828139 ORC6 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ORC6, siRNA

 Also Known As   

ORC6 siRNA (Human)

 Product Synonym Names    ORC6L; Origin recognition complex subunit 6
 Product Gene Name   

ORC6 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607213
 3D Structure    ModBase 3D Structure for Q9Y5N6
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    ORC6 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human ORC6 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of ORC6 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ORC6 sirna

   siRNA to inhibit ORC6 expression using RNA interference
 Applications Tested/Suitable for ORC6 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ORC6. It may not necessarily be applicable to this product.
 NCBI GI #    7657427
 NCBI GeneID    23594
 NCBI Accession #    NP_055136.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014321.3 [Other Products]
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 UniProt Primary Accession #    Q9Y5N6 [Other Products]
 UniProt Secondary Accession #    B3KN89 [Other Products]
 UniProt Related Accession #    Q9Y5N6 [Other Products]
 Molecular Weight    28,107 Da
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 NCBI Official Full Name    origin recognition complex subunit 6
 NCBI Official Synonym Full Names    origin recognition complex, subunit 6
 NCBI Official Symbol    ORC6 [Similar Products]
 NCBI Official Synonym Symbols   
ORC6L
[Similar Products]
 NCBI Protein Information    origin recognition complex subunit 6
 UniProt Protein Name    Origin recognition complex subunit 6
 Protein Family    Origin recognition complex
 UniProt Gene Name    ORC6 [Similar Products]
 UniProt Synonym Gene Names    ORC6L [Similar Products]
 UniProt Entry Name    ORC6_HUMAN
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 NCBI Summary for ORC6    The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
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 UniProt Comments for ORC6    ORC6L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: nucleoplasm; membrane; plasma membrane; nucleus; nuclear origin of replication recognition complex; origin recognition complex

Molecular Function: protein binding; DNA binding

Biological Process: mitotic cell cycle; DNA-dependent DNA replication; DNA replication; G1/S transition of mitotic cell cycle

Disease: Meier-gorlin Syndrome 3
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 Research Articles on ORC6    1. our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ORC6 sirnaPathways associated with ORC6 sirna
 Reference Product  PubMed Publications
 ORC1 sirna  >25 publications with ORC6 and ORC1
 ORC2 sirna  >14 publications with ORC6 and ORC2
 ORC4 sirna  >13 publications with ORC6 and ORC4
 ORC5 sirna  >9 publications with ORC6 and ORC5
 ORC3 sirna  >6 publications with ORC6 and ORC3
 CDC45 sirna  >2 publications with ORC6 and CDC45
 MCM5 sirna  >1 publications with ORC6 and MCM5
 MCM4 sirna  >1 publications with ORC6 and MCM4
 CDC7 sirna  >1 publications with ORC6 and CDC7
 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The ORC Complex At The Origin Of Replication Pathway antibodies  Assembly Of The ORC Complex At The Origin Of Replication Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 CDC6 Association With The ORC:origin Complex Pathway antibodies  CDC6 Association With The ORC:origin Complex Pathway Diagram
 CDT1 Association With The CDC6:ORC:origin Complex Pathway antibodies  CDT1 Association With The CDC6:ORC:origin Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with ORC6 sirnaOrgans/Tissues associated with ORC6 sirna
 Disease Name  Pubmed Publications
 Meier-Gorlin syndrome Antibodies  >8 publications with ORC6 and Meier-Gorlin syndrome
 Nervous System Diseases Antibodies  >1 publications with ORC6 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >6 publications with ORC6 and Bone
 Ear Antibodies  >4 publications with ORC6 and Ear
 Blood Antibodies  >1 publications with ORC6 and Blood
 Muscle Antibodies  >1 publications with ORC6 and Muscle
 Mouth Antibodies  >1 publications with ORC6 and Mouth
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