NP_081847.3
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
39,474 Da
NCBI Official Full Name
P2Y purinoceptor 12
NCBI Official Synonym Full Names
purinergic receptor P2Y, G-protein coupled 12
NCBI Official Synonym Symbols
P2Y12; 2900079B22Rik; 4921504D23Rik [Similar Products]
NCBI Protein Information
P2Y purinoceptor 12
UniProt Protein Name
P2Y purinoceptor 12
UniProt Synonym Gene Names
UniProt Entry Name
P2Y12_MOUSE
UniProt Comments for P2RY12
P2Y12: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. Defects in P2RY12 are the cause of bleeding disorder platelet-type 8 (BDPLT8). A condition characterized by mild to moderate mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of platelet response to ADP resulting in defective platelet aggregation. Belongs to the G-protein coupled receptor 1 family.
Protein type: Receptor, GPCR; Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1
Cellular Component: cell surface; membrane; mitochondrion; integral to plasma membrane; integral to membrane; plasma membrane; basal plasma membrane; intrinsic to membrane; caveola; external side of plasma membrane
Molecular Function: G-protein coupled receptor activity; signal transducer activity; purinergic nucleotide receptor activity, G-protein coupled; adenosine receptor activity, G-protein coupled; platelet ADP receptor activity
Biological Process: platelet activation; regulation of calcium ion transport; signal transduction; glial cell migration; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; negative regulation of cell differentiation; cell projection organization and biogenesis; hemostasis; protein kinase B signaling cascade; positive regulation of ion transport; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; adenosine receptor signaling pathway
Research Articles on P2RY12
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with P2RY12 sirna
Pathways associated with P2RY12 sirna
Diseases associated with P2RY12 sirna
Organs/Tissues associated with P2RY12 sirna
|