NP_035993.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
70,794 Da
NCBI Official Full Name
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform a
NCBI Official Synonym Full Names
3'-phosphoadenosine 5'-phosphosulfate synthase 1
NCBI Protein Information
bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Protein Name
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
UniProt Synonym Protein Names
Sulfurylase kinase 1; SK 1; SK1
UniProt Synonym Gene Names
Asapk; Atpsk1; Papss; PAPS synthase 1; PAPSS 1; SK 1; SK1; SAT [Similar Products]
UniProt Entry Name
PAPS1_MOUSE
UniProt Comments for PAPSS1
PAPSS1: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.
Protein type: Nucleotide Metabolism - purine; EC 2.7.7.4; Other Amino Acids Metabolism - selenoamino acid; EC 2.7.1.25; Energy Metabolism - sulfur; Kinase, other
Molecular Function: transferase activity; nucleotide binding; adenylylsulfate kinase activity; kinase activity; catalytic activity; ATP binding; sulfate adenylyltransferase (ATP) activity; nucleotidyltransferase activity
Biological Process: sulfate assimilation; metabolic process; phosphorylation; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
Research Articles on PAPSS1
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Products associated with PAPSS1 sirna
Pathways associated with PAPSS1 sirna
Diseases associated with PAPSS1 sirna
Organs/Tissues associated with PAPSS1 sirna
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