NP_001164430.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
95,906 Da
NCBI Official Full Name
cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform 2
NCBI Official Synonym Full Names
phosphodiesterase 6C, cGMP specific, cone, alpha prime
NCBI Official Synonym Symbols
NCBI Protein Information
cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
UniProt Protein Name
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
UniProt Synonym Protein Names
cGMP phosphodiesterase 6C
UniProt Entry Name
PDE6C_MOUSE
UniProt Comments for PDE6C
PDE6C: Defects in PDE6C are the cause of cone dystrophy type 4 (COD4). An early-onset cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Belongs to the cyclic nucleotide phosphodiesterase family.
Protein type: EC 3.1.4.35; Phosphodiesterase
Cellular Component: membrane; plasma membrane
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; phosphoric diester hydrolase activity; hydrolase activity; metal ion binding; nucleotide binding; cGMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity
Biological Process: phototransduction, visible light; retinal cone cell development; visual perception; sensory perception of light stimulus; response to stimulus; signal transduction
Research Articles on PDE6C
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Pathways associated with PDE6C sirna
Diseases associated with PDE6C sirna
Organs/Tissues associated with PDE6C sirna
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