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PDLIM5 sirna

Scan QR to view Datasheet Catalog #    MBS8214063 PDLIM5 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PDLIM5, siRNA

 Also Known As   

PDLIM5 siRNA (Mouse)

 Product Synonym Names    ENH; PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein
 Product Gene Name   

PDLIM5 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8CI51
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    PDLIM5 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse PDLIM5 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of PDLIM5 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PDLIM5 sirna

   siRNA to inhibit PDLIM5 expression using RNA interference
 Applications Tested/Suitable for PDLIM5 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for PDLIM5. It may not necessarily be applicable to this product.
 NCBI GI #    300069024
 NCBI GeneID    56376
 NCBI Accession #    NP_001177781.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190852.1 [Other Products]
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 UniProt Primary Accession #    Q8CI51 [Other Products]
 UniProt Secondary Accession #    Q3UGD0; Q9QYN0; Q9QYN1; Q9QYN2 [Other Products]
 UniProt Related Accession #    Q8CI51 [Other Products]
 Molecular Weight    26,346 Da
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 NCBI Official Full Name    PDZ and LIM domain protein 5 isoform ENH1e
 NCBI Official Synonym Full Names    PDZ and LIM domain 5
 NCBI Official Symbol    Pdlim5 [Similar Products]
 NCBI Official Synonym Symbols   
Enh; LIM; Enh1; Enh2; Enh3; C87059; AI987914; 1110001A05Rik
[Similar Products]
 NCBI Protein Information    PDZ and LIM domain protein 5
 UniProt Protein Name    PDZ and LIM domain protein 5
 UniProt Synonym Protein Names   
Enigma homolog; Enigma-like PDZ and LIM domains protein
 Protein Family    PDZ and LIM domain protein
 UniProt Gene Name    Pdlim5 [Similar Products]
 UniProt Synonym Gene Names    Enh [Similar Products]
 UniProt Entry Name    PDLI5_MOUSE
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 UniProt Comments for PDLIM5    LIM: an adaptor protein of the Enigma family. Contains three LIM domains and one PDZ domain. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. Enigma family proteins possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus.

Protein type: Adaptor/scaffold

Cellular Component: postsynaptic membrane; neuron projection; membrane; cytoplasm; postsynaptic density; plasma membrane; synapse; Z disc; cell junction; cytosol; actin cytoskeleton

Molecular Function: actinin binding; protein binding; protein kinase C binding; zinc ion binding; metal ion binding; protein N-terminus binding; actin binding

Biological Process: regulation of synaptogenesis
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 Research Articles on PDLIM5    1. PDLIM5 is involved in psychiatric disorders, including mood disorders
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDLIM5 sirnaDiseases associated with PDLIM5 sirna
 Reference Product  PubMed Publications
 Id2 sirna  >1 publications with PDLIM5 and Id2
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with PDLIM5 and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >3 publications with PDLIM5 and Prostatic Neoplasms
 Hypertrophy Antibodies  >2 publications with PDLIM5 and Hypertrophy
 Fibrosis Antibodies  >2 publications with PDLIM5 and Fibrosis
 Breast Neoplasms Antibodies  >2 publications with PDLIM5 and Breast Neoplasms
 Heart Diseases Antibodies  >2 publications with PDLIM5 and Heart Diseases
 Atherosclerosis Antibodies  >1 publications with PDLIM5 and Atherosclerosis
 Carcinoma, Squamous Cell Antibodies  >1 publications with PDLIM5 and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >1 publications with PDLIM5 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >1 publications with PDLIM5 and Nervous System Diseases
Organs/Tissues associated with PDLIM5 sirna
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with PDLIM5 and Brain
 Blood Antibodies  >7 publications with PDLIM5 and Blood
 Muscle Antibodies  >5 publications with PDLIM5 and Muscle
 Prostate Antibodies  >4 publications with PDLIM5 and Prostate
 Heart Antibodies  >3 publications with PDLIM5 and Heart
 Lung Antibodies  >1 publications with PDLIM5 and Lung
 Uncharacterized Tissue Antibodies  >1 publications with PDLIM5 and Uncharacterized Tissue
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