NP_788264.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
109,383 Da
NCBI Official Full Name
peroxisome proliferator-activated receptor gamma coactivator 1-beta
NCBI Official Synonym Full Names
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
NCBI Protein Information
peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProt Protein Name
Peroxisome proliferator-activated receptor gamma coactivator 1-beta
UniProt Synonym Gene Names
Perc; Pgc1; Pgc1b; Ppargc1; PGC-1-beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta [Similar Products]
UniProt Entry Name
PRGC2_RAT
UniProt Comments for PPARGC1B
PGC-1 beta: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Cellular Component: mitochondrion; Srb-mediator complex; nucleus
Molecular Function: nucleic acid binding; ligand-dependent nuclear receptor transcription coactivator activity; AF-2 domain binding; RNA binding; nucleotide binding; estrogen receptor binding; transcription factor binding; receptor activator activity
Biological Process: transcription from RNA polymerase II promoter; ossification; response to cAMP; estrogen receptor signaling pathway; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; response to glucocorticoid stimulus; actin filament organization; transcription from mitochondrial promoter; regulation of transcription, DNA-dependent; positive regulation of bone resorption; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of phosphorylation
Research Articles on PPARGC1B
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Products associated with PPARGC1B sirna
Pathways associated with PPARGC1B sirna
Diseases associated with PPARGC1B sirna
Organs/Tissues associated with PPARGC1B sirna
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