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PPP1R2 sirna

Scan QR to view Datasheet Catalog #    MBS8215256 PPP1R2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PPP1R2, siRNA

 Also Known As   

PPP1R2 siRNA (Rat)

 Product Synonym Names    IPP2; Protein phosphatase inhibitor 2; IPP-2
 Product Gene Name   

PPP1R2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P50411
 Host    Synthetic
 Species Reactivity    Rat
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 Specificity    PPP1R2 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat PPP1R2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of PPP1R2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PPP1R2 sirna

   siRNA to inhibit PPP1R2 expression using RNA interference
 Applications Tested/Suitable for PPP1R2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for PPP1R2. It may not necessarily be applicable to this product.
 NCBI GI #    41281691
 NCBI GeneID    192361
 NCBI Accession #    NP_620178.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_138823.2 [Other Products]
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 UniProt Primary Accession #    P50411 [Other Products]
 UniProt Secondary Accession #    Q56A32 [Other Products]
 UniProt Related Accession #    P50411 [Other Products]
 Molecular Weight    23,071 Da
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 NCBI Official Full Name    protein phosphatase inhibitor 2
 NCBI Official Synonym Full Names    protein phosphatase 1, regulatory (inhibitor) subunit 2
 NCBI Official Symbol    Ppp1r2 [Similar Products]
 NCBI Official Synonym Symbols   
IPP-2
[Similar Products]
 NCBI Protein Information    protein phosphatase inhibitor 2
 UniProt Protein Name    Protein phosphatase inhibitor 2
 Protein Family    Protein phosphatase inhibitor
 UniProt Gene Name    Ppp1r2 [Similar Products]
 UniProt Synonym Gene Names    Ipp2; IPP-2 [Similar Products]
 UniProt Entry Name    IPP2_RAT
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 NCBI Summary for PPP1R2    may play a role in the regulation of neurogenesis [RGD, Feb 2006]
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 UniProt Comments for PPP1R2    PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.

Protein type: Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit

Molecular Function: protein phosphatase inhibitor activity

Biological Process: glycogen metabolic process; negative regulation of catalytic activity; regulation of signal transduction; regulation of phosphoprotein phosphatase activity
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 Research Articles on PPP1R2    1. A novel calcium-induced IPP-2 activation pathway is found that is critical for homeostatic synaptic plasticity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PPP1R2 sirnaDiseases associated with PPP1R2 sirna
 Reference Product  PubMed Publications
 Ppp1cb sirna  >2 publications with PPP1R2 and Ppp1cb
 Ppp1cc sirna  >2 publications with PPP1R2 and Ppp1cc
 Ppp1r1a sirna  >1 publications with PPP1R2 and Ppp1r1a
 Ppp1ca sirna  >1 publications with PPP1R2 and Ppp1ca
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with PPP1R2 and Kidney Diseases
Organs/Tissues associated with PPP1R2 sirna
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with PPP1R2 and Brain
 Nerve Antibodies  >1 publications with PPP1R2 and Nerve
 Lung Antibodies  >1 publications with PPP1R2 and Lung
 Testis Antibodies  >1 publications with PPP1R2 and Testis
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