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PRND sirna

Scan QR to view Datasheet Catalog #    MBS8235506 PRND sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRND, siRNA

 Also Known As   

PRND siRNA (Human)

 Product Synonym Names    DPL; Prion-like protein doppel; PrPLP; Prion protein 2
 Product Gene Name   

PRND sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604263
 3D Structure    ModBase 3D Structure for Q9UKY0
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    PRND siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human PRND gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of PRND sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRND sirna

   siRNA to inhibit PRND expression using RNA interference
 Applications Tested/Suitable for PRND sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for PRND. It may not necessarily be applicable to this product.
 NCBI GI #    34335268
 NCBI GeneID    23627
 NCBI Accession #    NP_036541.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012409.3 [Other Products]
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 UniProt Primary Accession #    Q9UKY0 [Other Products]
 UniProt Secondary Accession #    Q9H311; Q9H312; Q9NTM4; A7U7M5 [Other Products]
 UniProt Related Accession #    Q9UKY0 [Other Products]
 Molecular Weight    20,293 Da
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 NCBI Official Full Name    prion-like protein doppel preproprotein
 NCBI Official Synonym Full Names    prion protein 2 (dublet)
 NCBI Official Symbol    PRND [Similar Products]
 NCBI Official Synonym Symbols   
DPL; PrPLP; DOPPEL; dJ1068H6.4
[Similar Products]
 NCBI Protein Information    prion-like protein doppel
 UniProt Protein Name    Prion-like protein doppel
 UniProt Synonym Protein Names   
PrPLP; Prion protein 2
 Protein Family    Prion-like protein doppel
 UniProt Gene Name    PRND [Similar Products]
 UniProt Synonym Gene Names    DPL [Similar Products]
 UniProt Entry Name    PRND_HUMAN
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 NCBI Summary for PRND    This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRND    PRND: This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: plasma membrane

Biological Process: protein homooligomerization
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 Research Articles on PRND    1. The association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with Alzheimer's disease and mild cognitive impairment, was evaluated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRND sirnaDiseases associated with PRND sirna
 Reference Product  PubMed Publications
 PRNP sirna  >73 publications with PRND and PRNP
 SPRN sirna  >9 publications with PRND and SPRN
 GNB2L1 sirna  >1 publications with PRND and GNB2L1
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >75 publications with PRND and Nervous System Diseases
 Nerve Degeneration Antibodies  >14 publications with PRND and Nerve Degeneration
 Disease Models, Animal Antibodies  >4 publications with PRND and Disease Models, Animal
 Inflammation Antibodies  >3 publications with PRND and Inflammation
 Vascular Diseases Antibodies  >2 publications with PRND and Vascular Diseases
 Bone Marrow Diseases Antibodies  >1 publications with PRND and Bone Marrow Diseases
 Adenocarcinoma Antibodies  >1 publications with PRND and Adenocarcinoma
 Kidney Diseases Antibodies  >1 publications with PRND and Kidney Diseases
 Atrophy Antibodies  >1 publications with PRND and Atrophy
 Learning Disorders Antibodies  >1 publications with PRND and Learning Disorders
Organs/Tissues associated with PRND sirna
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >61 publications with PRND and Brain
 Testis Antibodies  >32 publications with PRND and Testis
 Heart Antibodies  >3 publications with PRND and Heart
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