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PSMA4 sirna

Scan QR to view Datasheet Catalog #    MBS8210378 PSMA4 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSMA4, siRNA

 Also Known As   

PSMA4 siRNA (Rat)

 Product Synonym Names    Proteasome subunit alpha type-4; Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit L
 Product Gene Name   

PSMA4 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P21670
 Host    Synthetic
 Species Reactivity    Rat
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 Specificity    PSMA4 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat PSMA4 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of PSMA4 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PSMA4 sirna

   siRNA to inhibit PSMA4 expression using RNA interference
 Applications Tested/Suitable for PSMA4 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for PSMA4. It may not necessarily be applicable to this product.
 NCBI GI #    8394069
 NCBI GeneID    29671
 NCBI Accession #    NP_058977.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_017281.1 [Other Products]
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 UniProt Primary Accession #    P21670 [Other Products]
 UniProt Related Accession #    P21670 [Other Products]
 Molecular Weight    29,498 Da
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 NCBI Official Full Name    proteasome subunit alpha type-4
 NCBI Official Synonym Full Names    proteasome subunit alpha 4
 NCBI Official Symbol    Psma4 [Similar Products]
 NCBI Protein Information    proteasome subunit alpha type-4
 UniProt Protein Name    Proteasome subunit alpha type-4
 UniProt Synonym Protein Names   
Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit L
 Protein Family    Proteasome
 UniProt Gene Name    Psma4 [Similar Products]
 UniProt Entry Name    PSA4_RAT
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 NCBI Summary for PSMA4    component of the proteasome multicatalytic proteinase complex [RGD, Feb 2006]
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 UniProt Comments for PSMA4    PSMA4: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Belongs to the peptidase T1A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Proteasome complex; Cell cycle regulation; Protease; EC 3.4.25.1

Cellular Component: proteasome complex; proteasome core complex; intracellular membrane-bound organelle; cytoplasm; plasma membrane; nucleus

Molecular Function: threonine endopeptidase activity

Biological Process: ubiquitin-dependent protein catabolic process
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 Research Articles on PSMA4    1. Parkin interacts with the proteasome subunit alpha4
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PSMA4 sirnaPathways associated with PSMA4 sirna
 Reference Product  PubMed Publications
 Psma3 sirna  >4 publications with PSMA4 and Psma3
 Psma6 sirna  >2 publications with PSMA4 and Psma6
 Psma2 sirna  >2 publications with PSMA4 and Psma2
 Psmb5 sirna  >2 publications with PSMA4 and Psmb5
 Psma1 sirna  >2 publications with PSMA4 and Psma1
 Psmb2 sirna  >2 publications with PSMA4 and Psmb2
 Psmb1 sirna  >2 publications with PSMA4 and Psmb1
 Psmb7 sirna  >1 publications with PSMA4 and Psmb7
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
Diseases associated with PSMA4 sirnaOrgans/Tissues associated with PSMA4 sirna
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >6 publications with PSMA4 and Lung Neoplasms
 Carcinoma Antibodies  >3 publications with PSMA4 and Carcinoma
 Nervous System Diseases Antibodies  >1 publications with PSMA4 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with PSMA4 and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with PSMA4 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >7 publications with PSMA4 and Lung
 Brain Antibodies  >3 publications with PSMA4 and Brain
 Muscle Antibodies  >1 publications with PSMA4 and Muscle
 Liver Antibodies  >1 publications with PSMA4 and Liver
 Spleen Antibodies  >1 publications with PSMA4 and Spleen
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