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PTHLH sirna

Scan QR to view Datasheet Catalog #    MBS8212091 PTHLH sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   


 Product Synonym Names    PTHRP; Parathyroid hormone-related protein; PTH-rP; PTHrP; Parathyroid hormone-like protein; PLP
 Product Gene Name   

PTHLH sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P13085
 Host    Synthetic
 Species Reactivity    Rat
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 Specificity    PTHLH siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat PTHLH gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of PTHLH sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PTHLH sirna

   siRNA to inhibit PTHLH expression using RNA interference
 Applications Tested/Suitable for PTHLH sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for PTHLH. It may not necessarily be applicable to this product.
 NCBI GI #    6981438
 NCBI GeneID    24695
 NCBI Accession #    NP_036768.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012636.1 [Other Products]
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 UniProt Primary Accession #    P13085 [Other Products]
 UniProt Related Accession #    P13085 [Other Products]
 Molecular Weight    20,204 Da
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 NCBI Official Full Name    parathyroid hormone-related protein preproprotein
 NCBI Official Synonym Full Names    parathyroid hormone-like hormone
 NCBI Official Symbol    Pthlh [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    parathyroid hormone-related protein
 UniProt Protein Name    Parathyroid hormone-related protein
 UniProt Synonym Protein Names   
Parathyroid hormone-like protein; PLP
 Protein Family    Parathyroid hormone-related protein
 UniProt Gene Name    Pthlh [Similar Products]
 UniProt Synonym Gene Names    Pthrp; PTH-rP; PTHrP; PLP [Similar Products]
 UniProt Entry Name    PTHR_RAT
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 NCBI Summary for PTHLH    induces vasodilation; may play a neuroprotective role in response to ischemic brain injury [RGD, Feb 2006]
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 UniProt Comments for PTHLH    PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; extracellular region; intracellular; nucleus

Molecular Function: peptide hormone receptor binding; hormone activity

Biological Process: negative regulation of transcription factor activity; negative regulation of chondrocyte differentiation; G-protein signaling, adenylate cyclase activating pathway; bone mineralization; osteoblast development; epithelial cell differentiation; regulation of gene expression; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; protein processing; regulation of chondrocyte differentiation; skeletal development; surfactant homeostasis; alveolus development; endochondral ossification; endoderm development
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 Research Articles on PTHLH    1. Results show the expression of PTHrP and its receptor, PTHR1, in the majority of neurons and glial cells in the SCG of rats. Expression of PTHrP, but not PTHR1 in the cytoplasm of SCG neurons is influenced by ovarian activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PTHLH sirnaDiseases associated with PTHLH sirna
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Disease Name  Pubmed Publications
 Hypercalcemia Antibodies  >613 publications with PTHLH and Hypercalcemia
 Bone Resorption Antibodies  >140 publications with PTHLH and Bone Resorption
 Breast Neoplasms Antibodies  >125 publications with PTHLH and Breast Neoplasms
 Lung Neoplasms Antibodies  >104 publications with PTHLH and Lung Neoplasms
 Lung Diseases Antibodies  >89 publications with PTHLH and Lung Diseases
 Kidney Diseases Antibodies  >68 publications with PTHLH and Kidney Diseases
 Necrosis Antibodies  >48 publications with PTHLH and Necrosis
 Osteolysis Antibodies  >42 publications with PTHLH and Osteolysis
 Neoplasms, Experimental Antibodies  >39 publications with PTHLH and Neoplasms, Experimental
 Neuroendocrine Tumors Antibodies  >37 publications with PTHLH and Neuroendocrine Tumors
Organs/Tissues associated with PTHLH sirna
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >43 publications with PTHLH and Prostate
 Brain Antibodies  >28 publications with PTHLH and Brain
 Ovary Antibodies  >15 publications with PTHLH and Ovary
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