NP_001258067.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
19,889 Da
NCBI Official Full Name
RNA-binding protein 8A
NCBI Official Synonym Full Names
RNA binding motif protein 8A
NCBI Official Synonym Symbols
NCBI Protein Information
RNA-binding protein 8A
UniProt Protein Name
RNA-binding protein 8A
UniProt Synonym Protein Names
RNA-binding motif protein 8A; Ribonucleoprotein RBM8A
UniProt Synonym Gene Names
UniProt Entry Name
RBM8A_RAT
UniProt Comments for RBM8A
RBM8A: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway. Belongs to the RBM8A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Spliceosome; RNA splicing; Translation; RNA-binding
Cellular Component: nucleoplasm; cytoplasm; nuclear speck; nucleus
Molecular Function: mRNA binding; nucleotide binding
Biological Process: regulation of translation; mRNA transport; RNA splicing; mRNA catabolic process, nonsense-mediated decay; mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome
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Products associated with RBM8A sirna
Pathways associated with RBM8A sirna
Diseases associated with RBM8A sirna
Organs/Tissues associated with RBM8A sirna
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