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RC3H1 sirna

Scan QR to view Datasheet Catalog #    MBS8240255 RC3H1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RC3H1, siRNA

★Popular Item★
 Also Known As   

RC3H1 siRNA (Human)

 Product Synonym Names    KIAA2025; RNF198; Roquin-1; Roquin; RING finger and C3H zinc finger protein 1; RING finger and CCCH-type zinc finger domain-containing protein 1; RING finger protein 198
 Product Gene Name   

RC3H1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609424
 3D Structure    ModBase 3D Structure for Q5TC82
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    RC3H1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human RC3H1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of RC3H1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RC3H1 sirna

   siRNA to inhibit RC3H1 expression using RNA interference
 Applications Tested/Suitable for RC3H1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for RC3H1. It may not necessarily be applicable to this product.
 NCBI GI #    664806080
 NCBI GeneID    149041
 NCBI Accession #    NP_001287779.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001300850.1 [Other Products]
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 UniProt Primary Accession #    Q5TC82 [Other Products]
 UniProt Secondary Accession #    Q5W180; Q5W181; Q8IVE6; Q8N9V1; B3KVK1 [Other Products]
 UniProt Related Accession #    Q5TC82 [Other Products]
 Molecular Weight    124,842 Da
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 NCBI Official Full Name    roquin-1 isoform a
 NCBI Official Synonym Full Names    ring finger and CCCH-type domains 1
 NCBI Official Symbol    RC3H1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    roquin-1
 UniProt Protein Name    Roquin-1
 UniProt Synonym Protein Names   
RING finger and C3H zinc finger protein 1; RING finger and CCCH-type zinc finger domain-containing protein 1; RING finger protein 198
 Protein Family    Roquin
 UniProt Gene Name    RC3H1 [Similar Products]
 UniProt Synonym Gene Names    KIAA2025; RNF198; Roquin [Similar Products]
 UniProt Entry Name    RC3H1_HUMAN
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 NCBI Summary for RC3H1    This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for RC3H1    RC3H1: Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; RNA-binding

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: stress granule

Molecular Function: mRNA 3'-UTR binding; zinc ion binding

Biological Process: T cell proliferation; spleen development; negative regulation of germinal center formation; negative regulation of T-helper cell differentiation; B cell homeostasis; negative regulation of activated T cell proliferation; regulation of T cell receptor signaling pathway; protein ubiquitination; T cell homeostasis; cytoplasmic mRNA processing body assembly; negative regulation of B cell proliferation; regulation of mRNA stability; lymph node development; regulation of germinal center formation
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 Research Articles on RC3H1    1. Findings reveal that differential regulation of mRNAs by Regnase-1 and Roquin depends on their translation status and enables elaborate control of inflammation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with RC3H1 sirnaOrgans/Tissues associated with RC3H1 sirna
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >14 publications with RC3H1 and Immune System Diseases
 Inflammation Antibodies  >8 publications with RC3H1 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with RC3H1 and Disease Models, Animal
 Necrosis Antibodies  >3 publications with RC3H1 and Necrosis
 Kidney Diseases Antibodies  >3 publications with RC3H1 and Kidney Diseases
 Nephritis Antibodies  >2 publications with RC3H1 and Nephritis
 Poisoning Antibodies  >1 publications with RC3H1 and Poisoning
 Liver Diseases Antibodies  >1 publications with RC3H1 and Liver Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with RC3H1 and Drug-Related Side Effects and Adverse Reactions
 Drug-Induced Liver Injury Antibodies  >1 publications with RC3H1 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with RC3H1 and Blood
 Lymph Node Antibodies  >7 publications with RC3H1 and Lymph Node
 Liver Antibodies  >3 publications with RC3H1 and Liver
 Spleen Antibodies  >2 publications with RC3H1 and Spleen
 Lung Antibodies  >2 publications with RC3H1 and Lung
 Kidney Antibodies  >2 publications with RC3H1 and Kidney
 Bone Marrow Antibodies  >2 publications with RC3H1 and Bone Marrow
 Bone Antibodies  >2 publications with RC3H1 and Bone
 Intestine Antibodies  >2 publications with RC3H1 and Intestine
 Mouth Antibodies  >1 publications with RC3H1 and Mouth
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