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RELT sirna

Scan QR to view Datasheet Catalog #    MBS8207227 RELT sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RELT, siRNA

 Also Known As   

RELT siRNA (Human)

 Product Synonym Names    TNFRSF19L; Tumor necrosis factor receptor superfamily member 19L; Receptor expressed in lymphoid tissues
 Product Gene Name   

RELT sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611211
 3D Structure    ModBase 3D Structure for Q969Z4
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    RELT siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human RELT gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of RELT sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for RELT sirna

   siRNA to inhibit RELT expression using RNA interference
 Applications Tested/Suitable for RELT sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for RELT. It may not necessarily be applicable to this product.
 NCBI GI #    21361873
 NCBI GeneID    84957
 NCBI Accession #    NP_116260.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032871.3 [Other Products]
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 UniProt Primary Accession #    Q969Z4 [Other Products]
 UniProt Secondary Accession #    Q86V34; Q96JU1; Q9BUX7 [Other Products]
 UniProt Related Accession #    Q969Z4 [Other Products]
 Molecular Weight    46,092 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 19L
 NCBI Official Synonym Full Names    RELT tumor necrosis factor receptor
 NCBI Official Symbol    RELT [Similar Products]
 NCBI Official Synonym Symbols   
TRLT; TNFRSF19L
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 19L
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 19L
 UniProt Synonym Protein Names   
Receptor expressed in lymphoid tissues
 Protein Family    RELT-like protein
 UniProt Gene Name    RELT [Similar Products]
 UniProt Synonym Gene Names    TNFRSF19L [Similar Products]
 UniProt Entry Name    TR19L_HUMAN
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 NCBI Summary for RELT    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RELT    RELT: Mediates activation of NF-kappa-B. May play a role in T- cell activation. Belongs to the RELT family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: cytoplasm; integral to membrane; plasma membrane
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 Research Articles on RELT    1. report that overexpression of RELT or its homologues RELL1 and RELL2 in HEK 293 epithelial cells results in cell death with morphological characteristics consistent with the activation of an apoptotic pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RELT sirnaPathways associated with RELT sirna
 Reference Product  PubMed Publications
 RELL1 sirna  >3 publications with RELT and RELL1
 SERAC1 sirna  >2 publications with RELT and SERAC1
 STK39 sirna  >2 publications with RELT and STK39
 OXSR1 sirna  >2 publications with RELT and OXSR1
 TNFRSF19 sirna  >1 publications with RELT and TNFRSF19
 TRAF1 sirna  >1 publications with RELT and TRAF1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with RELT sirnaOrgans/Tissues associated with RELT sirna
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >11 publications with RELT and Liver Diseases
 Necrosis Antibodies  >7 publications with RELT and Necrosis
 Death Antibodies  >2 publications with RELT and Death
 Carcinoma, Hepatocellular Antibodies  >2 publications with RELT and Carcinoma, Hepatocellular
 Diabetes Mellitus Antibodies  >1 publications with RELT and Diabetes Mellitus
 Hemorrhage Antibodies  >1 publications with RELT and Hemorrhage
 Breast Neoplasms Antibodies  >1 publications with RELT and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with RELT and Neoplasms, Experimental
 Inflammation Antibodies  >1 publications with RELT and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with RELT and Blood
 Pancreas Antibodies  >1 publications with RELT and Pancreas
 Ascites Antibodies  >1 publications with RELT and Ascites
 Kidney Antibodies  >1 publications with RELT and Kidney
 Embryonic Tissue Antibodies  >1 publications with RELT and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with RELT and Lymph Node
 Lymph Antibodies  >1 publications with RELT and Lymph
 Spleen Antibodies  >1 publications with RELT and Spleen
 Vascular Antibodies  >1 publications with RELT and Vascular
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