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RHOBTB2 sirna

Scan QR to view Datasheet Catalog #    MBS8225415 RHOBTB2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

RHOBTB2 siRNA (Mouse)

 Product Synonym Names    DBC2; Rho-related BTB domain-containing protein 2; Deleted in breast cancer 2 gene protein homolog
 Product Gene Name   

RHOBTB2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q91V93
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    RHOBTB2 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse RHOBTB2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of RHOBTB2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for RHOBTB2 sirna

   siRNA to inhibit RHOBTB2 expression using RNA interference
 Applications Tested/Suitable for RHOBTB2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for RHOBTB2. It may not necessarily be applicable to this product.
 NCBI GI #    170932554
 NCBI GeneID    246710
 NCBI Accession #    NP_705734.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_153514.5 [Other Products]
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 UniProt Primary Accession #    Q91V93 [Other Products]
 UniProt Secondary Accession #    Q8BYU3; Q8K1A8 [Other Products]
 UniProt Related Accession #    Q91V93 [Other Products]
 Molecular Weight    82,650 Da
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 NCBI Official Full Name    rho-related BTB domain-containing protein 2
 NCBI Official Synonym Full Names    Rho-related BTB domain containing 2
 NCBI Official Symbol    Rhobtb2 [Similar Products]
 NCBI Official Synonym Symbols   
Dbc2; mKIAA0717; E130206H14Rik
[Similar Products]
 NCBI Protein Information    rho-related BTB domain-containing protein 2
 UniProt Protein Name    Rho-related BTB domain-containing protein 2
 UniProt Synonym Protein Names   
Deleted in breast cancer 2 gene protein homolog
 Protein Family    Rho-related BTB domain-containing protein
 UniProt Gene Name    Rhobtb2 [Similar Products]
 UniProt Synonym Gene Names    Dbc2 [Similar Products]
 UniProt Entry Name    RHBT2_MOUSE
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 UniProt Comments for RHOBTB2    RHOBTB2: is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Protein type: G protein, monomeric; G protein; G protein, monomeric, Rho

Cellular Component: intracellular

Molecular Function: protein binding; GTP binding; nucleotide binding

Biological Process: small GTPase mediated signal transduction
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 Research Articles on RHOBTB2    1. There is no connection between elevated expression of mDbc2/Rhobtb2 and a specific stage of mammary gland development, but this gene plays a critical role in the development of the nervous system.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RHOBTB2 sirnaDiseases associated with RHOBTB2 sirna
 Products by Pathway  Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >18 publications with RHOBTB2 and Breast Neoplasms
 Urinary Bladder Neoplasms Antibodies  >2 publications with RHOBTB2 and Urinary Bladder Neoplasms
 Necrosis Antibodies  >1 publications with RHOBTB2 and Necrosis
 Peripheral Nervous System Diseases Antibodies  >1 publications with RHOBTB2 and Peripheral Nervous System Diseases
Organs/Tissues associated with RHOBTB2 sirna
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with RHOBTB2 and Kidney
 Blood Antibodies  >2 publications with RHOBTB2 and Blood
 Pancreas Antibodies  >1 publications with RHOBTB2 and Pancreas
 Testis Antibodies  >1 publications with RHOBTB2 and Testis
 Muscle Antibodies  >1 publications with RHOBTB2 and Muscle
 Mammary Gland Antibodies  >1 publications with RHOBTB2 and Mammary Gland
 Embryonic Tissue Antibodies  >1 publications with RHOBTB2 and Embryonic Tissue
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