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RP2 sirna

Scan QR to view Datasheet Catalog #    MBS8205560 RP2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RP2, siRNA

 Also Known As   

RP2 siRNA (Human)

 Product Synonym Names    Protein XRP2
 Product Gene Name   

RP2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300757
 3D Structure    ModBase 3D Structure for O75695
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    RP2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human RP2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of RP2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RP2 sirna

   siRNA to inhibit RP2 expression using RNA interference
 Applications Tested/Suitable for RP2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for RP2. It may not necessarily be applicable to this product.
 NCBI GI #    170016081
 NCBI GeneID    6102
 NCBI Accession #    NP_008846.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006915.2 [Other Products]
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 UniProt Primary Accession #    O75695 [Other Products]
 UniProt Secondary Accession #    Q86XJ7; Q9NU67 [Other Products]
 UniProt Related Accession #    O75695 [Other Products]
 Molecular Weight    39,641 Da
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 NCBI Official Full Name    protein XRP2
 NCBI Official Synonym Full Names    retinitis pigmentosa 2 (X-linked recessive)
 NCBI Official Symbol    RP2 [Similar Products]
 NCBI Official Synonym Symbols   
XRP2; NME10; TBCCD2; NM23-H10; DELXp11.3
[Similar Products]
 NCBI Protein Information    protein XRP2
 UniProt Protein Name    Protein XRP2
 Protein Family    Protein
 UniProt Gene Name    RP2 [Similar Products]
 UniProt Entry Name    XRP2_HUMAN
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 NCBI Summary for RP2    The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly-folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death [provided by RefSeq, Jul 2008]
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 UniProt Comments for RP2    RP2: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. Defects in RP2 are the cause of retinitis pigmentosa type 2 (RP2); also known as X-linked retinitis pigmentosa 2 (XLRP-2). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the TBCC family.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: centriole; Golgi apparatus; cytoplasm; plasma membrane; cytoplasmic vesicle

Molecular Function: protein binding; GTP binding; unfolded protein binding; nucleoside diphosphate kinase activity; actin binding; GTPase activator activity; ATP binding

Biological Process: GTP biosynthetic process; protein folding; organelle organization and biogenesis; UTP biosynthetic process; cell morphogenesis; nucleoside diphosphate phosphorylation; cytoskeleton organization and biogenesis; protein transport; CTP biosynthetic process; visual perception; post-Golgi vesicle-mediated transport; post-chaperonin tubulin folding pathway; positive regulation of GTPase activity

Disease: Retinitis Pigmentosa 2
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 Research Articles on RP2    1. ellipsometric measurements of naRP2 demonstrated that its particular affinity for saturated phospholipids can be explained by its larger extent of insertion in this phospholipid monolayer compared to that in polyunsaturated phospholipid monolayers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RP2 sirnaPathways associated with RP2 sirna
 Reference Product  PubMed Publications
 RPGR sirna  >44 publications with RP2 and RPGR
 ARL3 sirna  >14 publications with RP2 and ARL3
 ARL2 sirna  >2 publications with RP2 and ARL2
 Products by Pathway  Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 Trafficking Of Myristoylated Proteins To The Cilium Pathway antibodies  Trafficking Of Myristoylated Proteins To The Cilium Pathway Diagram
Diseases associated with RP2 sirnaOrgans/Tissues associated with RP2 sirna
 Disease Name  Pubmed Publications
 Retinitis Pigmentosa 2 Antibodies  >25 publications with RP2 and Retinitis Pigmentosa 2
 Chromosome Aberrations Antibodies  >9 publications with RP2 and Chromosome Aberrations
 Disease Models, Animal Antibodies  >8 publications with RP2 and Disease Models, Animal
 Atrophy Antibodies  >7 publications with RP2 and Atrophy
 Lung Diseases Antibodies  >6 publications with RP2 and Lung Diseases
 Kidney Diseases Antibodies  >4 publications with RP2 and Kidney Diseases
 Lung Neoplasms Antibodies  >4 publications with RP2 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with RP2 and Neoplasms, Experimental
 Inflammation Antibodies  >3 publications with RP2 and Inflammation
 Fibrosis Antibodies  >2 publications with RP2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >111 publications with RP2 and Eye
 Blood Antibodies  >32 publications with RP2 and Blood
 Nerve Antibodies  >17 publications with RP2 and Nerve
 Kidney Antibodies  >17 publications with RP2 and Kidney
 Brain Antibodies  >13 publications with RP2 and Brain
 Connective Tissue Antibodies  >9 publications with RP2 and Connective Tissue
 Lung Antibodies  >8 publications with RP2 and Lung
 Embryonic Tissue Antibodies  >6 publications with RP2 and Embryonic Tissue
 Testis Antibodies  >6 publications with RP2 and Testis
 Skin Antibodies  >5 publications with RP2 and Skin
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