Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow siRNA rightarrow SGCD  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • OR2L5 Antibody
 • Soluble Glucoprotein 130 (SGP130) ELISA Kit
 • Filaggrin Antibody (AFA) ELISA Kit
 • Glutathione S Transferases (GST) ELISA Kit
 • Angiopoietin 4 (ANG4) ELISA Kit
 • Acetylcholine (ACH) ELISA Kit
 • Soluble Farnesoid X Receptor (FXR) ELISA Kit
 • Cystatin A (CSTA) ELISA Kit
 • Transcription Factor 20 (TCF20) ELISA Kit
 • Costimulatory Molecules B7H4 (B7-H4) ELISA Kit
 • Calsequestrin Antibody (AC) ELISA Kit
 • Oj Autoantibody (OJ-LLERS) ELISA Kit
 • Phosphorylated Acetyl-CoA Catboxylase (PACCASE) ELISA Kit
 • Insulin Like Growth Factor Binding Protein 3 (IGFBP3) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SGCD sirna

Scan QR to view Datasheet Catalog #    MBS8201358 SGCD sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SGCD, siRNA

 Also Known As   

SGCD siRNA (Mouse)

 Product Synonym Names    Delta-sarcoglycan; Delta-SG; 35 kDa dystrophin-associated glycoprotein; 35DAG
 Product Gene Name   

SGCD sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for P82347
 Host    Synthetic
 Species Reactivity    Mouse
Section Bar
 Specificity    SGCD siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
Section Bar
 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse SGCD gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of SGCD sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for SGCD sirna

   siRNA to inhibit SGCD expression using RNA interference
 Applications Tested/Suitable for SGCD sirna   

RNA Interference (RNAi)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SGCD. It may not necessarily be applicable to this product.
 NCBI GI #    6755484
 NCBI GeneID    24052
 NCBI Accession #    NP_036021.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011891.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P82347 [Other Products]
 UniProt Related Accession #    P82347 [Other Products]
 Molecular Weight    32,133 Da
Table BarTOPTable Bar
 NCBI Official Full Name    delta-sarcoglycan
 NCBI Official Synonym Full Names    sarcoglycan, delta (dystrophin-associated glycoprotein)
 NCBI Official Symbol    Sgcd [Similar Products]
 NCBI Official Synonym Symbols   
35kDa; delta-SG
[Similar Products]
 NCBI Protein Information    delta-sarcoglycan
 UniProt Protein Name    Delta-sarcoglycan
 UniProt Synonym Protein Names   
35 kDa dystrophin-associated glycoprotein; 35DAG
 Protein Family    Delta-sarcoglycan
 UniProt Gene Name    Sgcd [Similar Products]
 UniProt Synonym Gene Names    Delta-SG; 35DAG [Similar Products]
 UniProt Entry Name    SGCD_MOUSE
Section Bar
 UniProt Comments for SGCD    SGCD: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F). LGMD2F is an autosomal recessive disorder. Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the sarcoglycan beta/delta/gamma/zeta family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Dystrophin complex; Membrane protein, integral

Cellular Component: dystrophin-associated glycoprotein complex; dystroglycan complex; cytoskeleton; membrane; integral to plasma membrane; cytoplasm; plasma membrane; integral to membrane; sarcoglycan complex; sarcolemma

Molecular Function: protein binding

Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development
Table BarTOPTable Bar
 Research Articles on SGCD    1. Myocardial expression of p.S151A cDNA, similar to intact Sgcd cDNA, restores cardiac function, although not being able to prevent myocardial histopathology in Sgcd-null mice completely.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with SGCD sirnaPathways associated with SGCD sirna
 Reference Product  PubMed Publications
 Sgcg sirna  >10 publications with SGCD and Sgcg
 Sgca sirna  >9 publications with SGCD and Sgca
 Sgcb sirna  >8 publications with SGCD and Sgcb
 Dmd sirna  >3 publications with SGCD and Dmd
 Cryaa sirna  >1 publications with SGCD and Cryaa
 Sgcz sirna  >1 publications with SGCD and Sgcz
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Viral Myocarditis Pathway antibodies  Viral Myocarditis Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
Diseases associated with SGCD sirnaOrgans/Tissues associated with SGCD sirna
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >17 publications with SGCD and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >15 publications with SGCD and Disease Models, Animal
 Cardiomyopathies Antibodies  >14 publications with SGCD and Cardiomyopathies
 Fibrosis Antibodies  >12 publications with SGCD and Fibrosis
 Necrosis Antibodies  >7 publications with SGCD and Necrosis
 Limb-girdle muscular dystrophy type 2F Antibodies  >4 publications with SGCD and Limb-girdle muscular dystrophy type 2F
 Lung Diseases Antibodies  >2 publications with SGCD and Lung Diseases
 Hypertrophy Antibodies  >2 publications with SGCD and Hypertrophy
 Inflammation Antibodies  >2 publications with SGCD and Inflammation
 Cardiomyopathy, Hypertrophic Antibodies  >1 publications with SGCD and Cardiomyopathy, Hypertrophic
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with SGCD and Lung
 Embryonic Tissue Antibodies  >1 publications with SGCD and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions