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SIPA1L1 sirna

Scan QR to view Datasheet Catalog #    MBS8218857 SIPA1L1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

SIPA1L1 siRNA (Rat)

 Product Synonym Names    SPA1; Signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; SPA-1-like protein p1294; Spine-associated Rap GTPase-activating protein; SPAR
 Product Gene Name   

SIPA1L1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for O35412
 Host    Synthetic
 Species Reactivity    Rat
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 Specificity    SIPA1L1 siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat SIPA1L1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of SIPA1L1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SIPA1L1 sirna

   siRNA to inhibit SIPA1L1 expression using RNA interference
 Applications Tested/Suitable for SIPA1L1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for SIPA1L1. It may not necessarily be applicable to this product.
 NCBI GI #    21326463
 NCBI GeneID    246212
 NCBI Accession #    NP_647546.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_139330.1 [Other Products]
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 UniProt Primary Accession #    O35412 [Other Products]
 UniProt Related Accession #    O35412 [Other Products]
 Molecular Weight    201,925 Da
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 NCBI Official Full Name    signal-induced proliferation-associated 1-like protein 1
 NCBI Official Synonym Full Names    signal-induced proliferation-associated 1 like 1
 NCBI Official Symbol    Sipa1l1 [Similar Products]
 NCBI Official Synonym Symbols   
SPAL; Spa1; Spar; Spa-1
[Similar Products]
 NCBI Protein Information    signal-induced proliferation-associated 1-like protein 1
 UniProt Protein Name    Signal-induced proliferation-associated 1-like protein 1
 UniProt Synonym Protein Names   
SPA-1-like protein p1294; Spine-associated Rap GTPase-activating protein; SPAR
 Protein Family    Signal-induced proliferation-associated 1-like protein
 UniProt Gene Name    Sipa1l1 [Similar Products]
 UniProt Synonym Gene Names    Spa1; SIPA1-like protein 1; SPAR [Similar Products]
 UniProt Entry Name    SI1L1_RAT
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 NCBI Summary for SIPA1L1    GTPase-activating protein (GAP) that is specific for Rap1; may be involved in cytoskeletal organization of neurons [RGD, Feb 2006]
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 UniProt Comments for SIPA1L1    SIPA1L1: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Ras; GAPs

Cellular Component: postsynaptic membrane; cytoskeleton; protein complex; cell soma; cytoplasm; postsynaptic density; dendritic spine; cell junction

Molecular Function: actin filament binding; protein binding; ephrin receptor binding; ubiquitin protein ligase binding; protein complex binding; protein kinase binding; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; regulation of dendrite morphogenesis; actin cytoskeleton reorganization; ephrin receptor signaling pathway; regulation of synaptic plasticity; regulation of axonogenesis; positive regulation of GTPase activity
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 Research Articles on SIPA1L1    1. Prenatal stress increased spar in thr hippocampus of the offspring at adulthood in rats
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SIPA1L1 sirnaPathways associated with SIPA1L1 sirna
 Reference Product  PubMed Publications
 Prosapip1 sirna  >1 publications with SIPA1L1 and Prosapip1
 Products by Pathway  Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
Diseases associated with SIPA1L1 sirnaOrgans/Tissues associated with SIPA1L1 sirna
 Disease Name  Pubmed Publications
 Pregnancy Complications Antibodies  >2 publications with SIPA1L1 and Pregnancy Complications
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with SIPA1L1 and Prenatal Exposure Delayed Effects
 Embryo Loss Antibodies  >1 publications with SIPA1L1 and Embryo Loss
 Nervous System Diseases Antibodies  >1 publications with SIPA1L1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >1 publications with SIPA1L1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with SIPA1L1 and Brain
 Lung Antibodies  >1 publications with SIPA1L1 and Lung
 Placenta Antibodies  >1 publications with SIPA1L1 and Placenta
 Embryonic Tissue Antibodies  >1 publications with SIPA1L1 and Embryonic Tissue
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