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SIRT7 sirna

Scan QR to view Datasheet Catalog #    MBS8238194 SIRT7 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

SIRT7 siRNA (Mouse)

 Product Synonym Names    SIR2L7; NAD-dependent protein deacetylase sirtuin-7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7
 Product Gene Name   

SIRT7 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8BKJ9
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    SIRT7 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse SIRT7 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of SIRT7 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SIRT7 sirna

   siRNA to inhibit SIRT7 expression using RNA interference
 Applications Tested/Suitable for SIRT7 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for SIRT7. It may not necessarily be applicable to this product.
 NCBI GI #    165932356
 NCBI GeneID    209011
 NCBI Accession #    NP_694696.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_153056.2 [Other Products]
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 UniProt Primary Accession #    Q8BKJ9 [Other Products]
 UniProt Secondary Accession #    Q6X7B7; Q8QZZ5; A2ABY7 [Other Products]
 UniProt Related Accession #    Q8BKJ9 [Other Products]
 Molecular Weight    45,146 Da
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 NCBI Official Full Name    NAD-dependent protein deacetylase sirtuin-7
 NCBI Official Synonym Full Names    sirtuin 7
 NCBI Official Symbol    Sirt7 [Similar Products]
 NCBI Protein Information    NAD-dependent protein deacetylase sirtuin-7
 UniProt Protein Name    NAD-dependent protein deacetylase sirtuin-7
 UniProt Synonym Protein Names   
Regulatory protein SIR2 homolog 7; SIR2-like protein 7
 Protein Family    NAD-dependent protein deacetylase
 UniProt Gene Name    Sirt7 [Similar Products]
 UniProt Synonym Gene Names    Sir2l7 [Similar Products]
 UniProt Entry Name    SIR7_MOUSE
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 UniProt Comments for SIRT7    SIRT7: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation. Belongs to the sirtuin family. Class IV subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Deacetylase; EC 3.5.1.-

Cellular Component: nucleolus organizer region; cytoplasm; nucleolus; nucleus

Molecular Function: N-acetylgalactosamine-6-phosphate deacetylase activity; (3,5-dichlorophenylurea)acetate amidohydrolase activity; N2-acetyl-L-lysine deacetylase activity; iprodione amidohydrolase activity; hydrolase activity; indoleacetamide hydrolase activity; metal ion binding; protein N-terminal asparagine amidohydrolase activity; chromatin binding; histone deacetylase activity; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; O-succinylbenzoate synthase activity

Biological Process: activation of transcription on exit from mitosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; rRNA transcription
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 Research Articles on SIRT7    1. SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SIRT7 sirnaDiseases associated with SIRT7 sirna
 Reference Product  PubMed Publications
 Mybbp1a sirna  >3 publications with SIRT7 and Mybbp1a
 Hdac11 sirna  >2 publications with SIRT7 and Hdac11
 Hdac5 sirna  >1 publications with SIRT7 and Hdac5
 Trp53 sirna  >1 publications with SIRT7 and Trp53
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12 publications with SIRT7 and Inflammation
 Liver Diseases Antibodies  >7 publications with SIRT7 and Liver Diseases
 Hypertrophy Antibodies  >6 publications with SIRT7 and Hypertrophy
 Liver Neoplasms Antibodies  >6 publications with SIRT7 and Liver Neoplasms
 Heart Diseases Antibodies  >6 publications with SIRT7 and Heart Diseases
 Vascular Diseases Antibodies  >5 publications with SIRT7 and Vascular Diseases
 Fibrosis Antibodies  >5 publications with SIRT7 and Fibrosis
 Fatty Liver Antibodies  >4 publications with SIRT7 and Fatty Liver
 Neoplasms, Experimental Antibodies  >3 publications with SIRT7 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >3 publications with SIRT7 and Carcinoma, Hepatocellular
Organs/Tissues associated with SIRT7 sirna
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >15 publications with SIRT7 and Liver
 Heart Antibodies  >12 publications with SIRT7 and Heart
 Blood Antibodies  >12 publications with SIRT7 and Blood
 Muscle Antibodies  >8 publications with SIRT7 and Muscle
 Brain Antibodies  >6 publications with SIRT7 and Brain
 Lung Antibodies  >5 publications with SIRT7 and Lung
 Adipose Tissue Antibodies  >3 publications with SIRT7 and Adipose Tissue
 Kidney Antibodies  >3 publications with SIRT7 and Kidney
 Skin Antibodies  >3 publications with SIRT7 and Skin
 Bladder Antibodies  >2 publications with SIRT7 and Bladder
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