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SKA2 sirna

Scan QR to view Datasheet Catalog #    MBS8228759 SKA2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

SKA2 siRNA (Mouse)

 Product Synonym Names    FAM33A; Spindle and kinetochore-associated protein 2; Protein FAM33A
 Product Gene Name   

SKA2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9CR46
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    SKA2 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse SKA2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of SKA2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SKA2 sirna

   siRNA to inhibit SKA2 expression using RNA interference
 Applications Tested/Suitable for SKA2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for SKA2. It may not necessarily be applicable to this product.
 NCBI GI #    13384752
 NCBI GeneID    66140
 NCBI Accession #    NP_079653.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_025377.3 [Other Products]
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 UniProt Primary Accession #    Q9CR46 [Other Products]
 UniProt Secondary Accession #    B2KGY1 [Other Products]
 UniProt Related Accession #    Q9CR46 [Other Products]
 Molecular Weight    13,725 Da
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 NCBI Official Full Name    spindle and kinetochore-associated protein 2
 NCBI Official Synonym Full Names    spindle and kinetochore associated complex subunit 2
 NCBI Official Symbol    Ska2 [Similar Products]
 NCBI Official Synonym Symbols   
C78640; Fam33a; 1110001A07Rik
[Similar Products]
 NCBI Protein Information    spindle and kinetochore-associated protein 2
 UniProt Protein Name    Spindle and kinetochore-associated protein 2
 UniProt Synonym Protein Names   
Protein FAM33A
 Protein Family    Spindle and kinetochore-associated protein
 UniProt Gene Name    Ska2 [Similar Products]
 UniProt Synonym Gene Names    Fam33a [Similar Products]
 UniProt Entry Name    SKA2_MOUSE
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 UniProt Comments for SKA2    SKA2: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization. Belongs to the SKA2 family.

Cellular Component: kinetochore; microtubule; cytoskeleton; spindle microtubule; cytoplasm; outer kinetochore of condensed chromosome; chromosome; chromosome, pericentric region

Molecular Function: microtubule binding

Biological Process: mitosis; cell division; cell cycle; regulation of microtubule polymerization or depolymerization; mitotic anaphase; chromosome segregation
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 Research Articles on SKA2    1. The Skas subunit was only localized on spindle microtubules from the Pro-MI to MII stages in mouse oocyte meiosis and knockdown by Morpholino injection into mouse oocytes resulted in spindle movement defects and enlarged polar bodies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SKA2 sirnaPathways associated with SKA2 sirna
 Reference Product  PubMed Publications
 Ska1 sirna  >12 publications with SKA2 and Ska1
 Ska3 sirna  >9 publications with SKA2 and Ska3
 Ndc80 sirna  >3 publications with SKA2 and Ndc80
 Dsn1 sirna  >1 publications with SKA2 and Dsn1
 Casc5 sirna  >1 publications with SKA2 and Casc5
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 RHO GTPase Effectors Pathway antibodies  RHO GTPase Effectors Pathway Diagram
 RHO GTPases Activate Formins Pathway antibodies  RHO GTPases Activate Formins Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
 Separation Of Sister Chromatids Pathway antibodies  Separation Of Sister Chromatids Pathway Diagram
Diseases associated with SKA2 sirnaOrgans/Tissues associated with SKA2 sirna
 Disease Name  Pubmed Publications
 Nephritis Antibodies  >2 publications with SKA2 and Nephritis
 Breast Neoplasms Antibodies  >2 publications with SKA2 and Breast Neoplasms
 Depressive Disorder Antibodies  >1 publications with SKA2 and Depressive Disorder
 Neoplasms, Experimental Antibodies  >1 publications with SKA2 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with SKA2 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with SKA2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with SKA2 and Brain
 Lung Antibodies  >3 publications with SKA2 and Lung
 Liver Antibodies  >2 publications with SKA2 and Liver
 Bone Antibodies  >1 publications with SKA2 and Bone
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