NP_001192240.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
110,694 Da
NCBI Official Full Name
solute carrier family 12 member 3 isoform 1
NCBI Official Synonym Full Names
solute carrier family 12, member 3
NCBI Protein Information
solute carrier family 12 member 3
UniProt Protein Name
Solute carrier family 12 member 3
UniProt Synonym Protein Names
Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter
UniProt Synonym Gene Names
UniProt Entry Name
S12A3_MOUSE
UniProt Comments for SLC12A3
NCCT: Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. Interacts with KLHL3. Predominant in kidney. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family
Cellular Component: membrane; apical plasma membrane; integral to membrane; plasma membrane; cytosol; vesicle
Molecular Function: sodium ion transmembrane transporter activity; transporter activity; symporter activity; sodium:chloride symporter activity; cation:chloride symporter activity
Biological Process: transport; sodium ion transport; ion transport; chloride transport; transmembrane transport
Research Articles on SLC12A3
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Products associated with SLC12A3 sirna
Pathways associated with SLC12A3 sirna
Diseases associated with SLC12A3 sirna
Organs/Tissues associated with SLC12A3 sirna
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