NP_035595.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
279,865 Da
NCBI Official Full Name
spectrin alpha chain, erythrocytic 1
NCBI Official Synonym Full Names
spectrin alpha, erythrocytic 1
NCBI Official Synonym Symbols
ha; ihj; sph; nmf4; Spna1; Spna-1; AF093576; AI451697 [Similar Products]
NCBI Protein Information
spectrin alpha chain, erythrocytic 1
UniProt Protein Name
Spectrin alpha chain, erythrocytic 1
UniProt Synonym Protein Names
Erythroid alpha-spectrin
UniProt Synonym Gene Names
UniProt Entry Name
SPTA1_MOUSE
UniProt Comments for SPTA1
SPTA1: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTA1 are the cause of elliptocytosis type 2 (EL2). EL2 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTA1 are a cause of hereditary pyropoikilocytosis (HPP). HPP is an autosomal recessive disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells. Defects in SPTA1 are the cause of spherocytosis type 3 (SPH3); also known as hereditary spherocytosis type 3 (HS3). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH3 is characterized by severe hemolytic anemia. Inheritance is autosomal recessive. Belongs to the spectrin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Cellular Component: cortical cytoskeleton; spectrin; cytoskeleton; membrane; cytoplasm
Molecular Function: protein heterodimerization activity; metal ion binding; calcium ion binding; actin binding
Biological Process: regulation of cell shape; positive regulation of protein binding; plasma membrane organization and biogenesis; actin filament capping; hemopoiesis; positive regulation of T cell proliferation; actin cytoskeleton organization and biogenesis; lymphocyte homeostasis; porphyrin biosynthetic process
Research Articles on SPTA1
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Products associated with SPTA1 sirna
Pathways associated with SPTA1 sirna
Diseases associated with SPTA1 sirna
Organs/Tissues associated with SPTA1 sirna
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