NP_001001433.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,074 Da
NCBI Official Full Name
syntaxin-16 isoform a
NCBI Official Synonym Full Names
syntaxin 16
NCBI Official Synonym Symbols
NCBI Protein Information
syntaxin-16
UniProt Protein Name
Syntaxin-16
UniProt Synonym Gene Names
UniProt Entry Name
STX16_HUMAN
NCBI Summary for STX16
This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]
UniProt Comments for STX16
STX16: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B). Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. Belongs to the syntaxin family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Membrane protein, integral
Chromosomal Location of Human Ortholog: 20q13.32
Cellular Component: Golgi apparatus; Golgi cisterna; focal adhesion; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane; endomembrane system; trans-Golgi network; cytosol; Golgi membrane; SNARE complex; membrane; perinuclear region of cytoplasm; cytoplasm; nucleolus
Molecular Function: SNAP receptor activity; protein binding; SNARE binding; syntaxin binding
Biological Process: vesicle fusion; intracellular protein transport; intra-Golgi vesicle-mediated transport; vesicle docking; retrograde transport, endosome to Golgi
Disease: Pseudohypoparathyroidism, Type Ib
Research Articles on STX16
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Products associated with STX16 sirna
Pathways associated with STX16 sirna
Diseases associated with STX16 sirna
Organs/Tissues associated with STX16 sirna
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