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THRB sirna

Scan QR to view Datasheet Catalog #    MBS8229008 THRB sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

THRB, siRNA

★Popular Item★
 Also Known As   

THRB siRNA (Human)

 Product Synonym Names    ERBA2; NR1A2; THR1; Thyroid hormone receptor beta; Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta
 Product Gene Name   

THRB sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    145650
 3D Structure    ModBase 3D Structure for P10828
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 Species Reactivity    Human
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 Specificity    THRB siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Source    Synthetic
 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human THRB gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of THRB sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for THRB sirna

   siRNA to inhibit THRB expression using RNA interference
 Applications Tested/Suitable for THRB sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for THRB. It may not necessarily be applicable to this product.
 NCBI GI #    40806162
 NCBI GeneID    7068
 NCBI Accession #    NP_000452.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000461.4 [Other Products]
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 UniProt Primary Accession #    P10828 [Other Products]
 UniProt Secondary Accession #    P37243; Q13986; Q3KP35; Q6WGL2; Q9UD41; B3KU79 [Other Products]
 UniProt Related Accession #    P10828 [Other Products]
 Molecular Weight    54,449 Da
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 NCBI Official Full Name    thyroid hormone receptor beta
 NCBI Official Synonym Full Names    thyroid hormone receptor, beta
 NCBI Official Symbol    THRB [Similar Products]
 NCBI Official Synonym Symbols   
GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA
[Similar Products]
 NCBI Protein Information    thyroid hormone receptor beta
 UniProt Protein Name    Thyroid hormone receptor beta
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta
 Protein Family    Thyroid hormone receptor
 UniProt Gene Name    THRB [Similar Products]
 UniProt Synonym Gene Names    ERBA2; NR1A2; THR1 [Similar Products]
 UniProt Entry Name    THB_HUMAN
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 NCBI Summary for THRB    The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for THRB    TR-beta1: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Homolog of the viral oncogene erbB. Two splice variant isoforms have been described.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: nucleoplasm; nuclear chromatin; nucleus

Molecular Function: protein binding; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; chromatin DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity; transcription corepressor activity

Biological Process: negative regulation of female receptivity; transcription initiation from RNA polymerase II promoter; organ morphogenesis; sensory perception of sound; female courtship behavior; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling; negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction

Disease: Thyroid Hormone Resistance, Selective Pituitary; Thyroid Hormone Resistance, Generalized, Autosomal Dominant; Thyroid Hormone Resistance, Generalized, Autosomal Recessive
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 Research Articles on THRB    1. data indicated altered mineral metabolism in adults and children with resistance to thyroid hormone due to mutations in the THRB gene
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with THRB sirnaPathways associated with THRB sirna
 Reference Product  PubMed Publications
 RXRA sirna  >2 publications with THRB and RXRA
 NCOR1 sirna  >2 publications with THRB and NCOR1
 ESR1 sirna  >1 publications with THRB and ESR1
 RXRG sirna  >1 publications with THRB and RXRG
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Thyroid Hormone Signaling Pathway antibodies  Thyroid Hormone Signaling Pathway Diagram
Diseases associated with THRB sirnaOrgans/Tissues associated with THRB sirna
 Disease Name  Pubmed Publications
 Thyroid Diseases Antibodies  >60 publications with THRB and Thyroid Diseases
 Thyroid Hormone Resistance Syndrome Antibodies  >33 publications with THRB and Thyroid Hormone Resistance Syndrome
 Nervous System Diseases Antibodies  >14 publications with THRB and Nervous System Diseases
 Disease Models, Animal Antibodies  >10 publications with THRB and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >9 publications with THRB and Cardiovascular Diseases
 Kidney Diseases Antibodies  >8 publications with THRB and Kidney Diseases
 Hyperplasia Antibodies  >6 publications with THRB and Hyperplasia
 Neoplasms, Experimental Antibodies  >5 publications with THRB and Neoplasms, Experimental
 Brain Diseases Antibodies  >5 publications with THRB and Brain Diseases
 Liver Diseases Antibodies  >3 publications with THRB and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with THRB and Brain
 Liver Antibodies  >18 publications with THRB and Liver
 Lung Antibodies  >12 publications with THRB and Lung
 Kidney Antibodies  >12 publications with THRB and Kidney
 Pituitary Gland Antibodies  >11 publications with THRB and Pituitary Gland
 Eye Antibodies  >9 publications with THRB and Eye
 Ear Antibodies  >8 publications with THRB and Ear
 Vascular Antibodies  >7 publications with THRB and Vascular
 Muscle Antibodies  >6 publications with THRB and Muscle
 Prostate Antibodies  >5 publications with THRB and Prostate
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