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TICAM2 sirna

Scan QR to view Datasheet Catalog #    MBS8240450 TICAM2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TICAM2, siRNA

 Also Known As   

TICAM2 siRNA (Mouse)

 Product Synonym Names    TIRP; TRAM; TIR domain-containing adapter molecule 2; TICAM-2; TRIF-related adapter molecule; Toll/interleukin-1 receptor domain-containing protein
 Product Gene Name   

TICAM2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8BJQ4
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    TICAM2 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse TICAM2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of TICAM2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for TICAM2 sirna

   siRNA to inhibit TICAM2 expression using RNA interference
 Applications Tested/Suitable for TICAM2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for TICAM2. It may not necessarily be applicable to this product.
 NCBI GI #    27734184
 NCBI GeneID    225471
 NCBI Accession #    NP_775570.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_173394.3 [Other Products]
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 UniProt Primary Accession #    Q8BJQ4 [Other Products]
 UniProt Secondary Accession #    Q3U996 [Other Products]
 UniProt Related Accession #    Q8BJQ4 [Other Products]
 Molecular Weight    26,362 Da
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 NCBI Official Full Name    TIR domain-containing adapter molecule 2
 NCBI Official Synonym Full Names    toll-like receptor adaptor molecule 2
 NCBI Official Symbol    Ticam2 [Similar Products]
 NCBI Official Synonym Symbols   
TRAM; Tirp; Trif; TICAM-2; B430113A10
[Similar Products]
 NCBI Protein Information    TIR domain-containing adapter molecule 2
 UniProt Protein Name    TIR domain-containing adapter molecule 2
 UniProt Synonym Protein Names   
TRIF-related adapter molecule; Toll/interleukin-1 receptor domain-containing protein
 Protein Family    TIR domain-containing adapter molecule
 UniProt Gene Name    Ticam2 [Similar Products]
 UniProt Synonym Gene Names    Tirp; Tram; TICAM-2 [Similar Products]
 UniProt Entry Name    TCAM2_MOUSE
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 UniProt Comments for TICAM2    TICAM2: a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2.

Protein type: Adaptor/scaffold

Cellular Component: Golgi apparatus; interleukin-1 receptor complex; membrane; endoplasmic reticulum; cytoplasm; early endosome; late endosome; plasma membrane; endosome

Molecular Function: signal transducer activity; protein binding; interleukin-1 receptor binding; protein heterodimerization activity; phospholipid binding

Biological Process: positive regulation of interferon-gamma production; positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; innate immune response; positive regulation of interleukin-6 production; regulation of interferon-beta biosynthetic process; regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction; inflammatory response; regulation of cytokine production
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 Research Articles on TICAM2    1. Type I interferon has a role in the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TICAM2 sirnaPathways associated with TICAM2 sirna
 Reference Product  PubMed Publications
 Myd88 sirna  >30 publications with TICAM2 and Myd88
 Tlr4 sirna  >25 publications with TICAM2 and Tlr4
 Ticam1 sirna  >22 publications with TICAM2 and Ticam1
 Sarm1 sirna  >7 publications with TICAM2 and Sarm1
 Irf3 sirna  >7 publications with TICAM2 and Irf3
 Traf6 sirna  >7 publications with TICAM2 and Traf6
 Tlr3 sirna  >6 publications with TICAM2 and Tlr3
 Irak1 sirna  >3 publications with TICAM2 and Irak1
 Irak4 sirna  >1 publications with TICAM2 and Irak4
 Ripk1 sirna  >1 publications with TICAM2 and Ripk1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 IKK Complex Recruitment Mediated By RIP1 Pathway antibodies  IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Ligand-dependent Caspase Activation Pathway antibodies  Ligand-dependent Caspase Activation Pathway Diagram
 MyD88-independent TLR3/TLR4 Cascade Pathway antibodies  MyD88-independent TLR3/TLR4 Cascade Pathway Diagram
Diseases associated with TICAM2 sirnaOrgans/Tissues associated with TICAM2 sirna
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with TICAM2 and Inflammation
 Necrosis Antibodies  >5 publications with TICAM2 and Necrosis
 Atherosclerosis Antibodies  >2 publications with TICAM2 and Atherosclerosis
 Nervous System Diseases Antibodies  >1 publications with TICAM2 and Nervous System Diseases
 Liver Diseases Antibodies  >1 publications with TICAM2 and Liver Diseases
 Hypertrophy Antibodies  >1 publications with TICAM2 and Hypertrophy
 Leukemia Antibodies  >1 publications with TICAM2 and Leukemia
 Kidney Diseases Antibodies  >1 publications with TICAM2 and Kidney Diseases
 Drug-Induced Liver Injury Antibodies  >1 publications with TICAM2 and Drug-Induced Liver Injury
 Brain Injuries Antibodies  >1 publications with TICAM2 and Brain Injuries
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with TICAM2 and Bone
 Bone Marrow Antibodies  >2 publications with TICAM2 and Bone Marrow
 Joint Antibodies  >1 publications with TICAM2 and Joint
 Skin Antibodies  >1 publications with TICAM2 and Skin
 Thymus Antibodies  >1 publications with TICAM2 and Thymus
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