Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow siRNA rightarrow TRAF1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • NF-kappaB p100-p52 (Ab-869) (NFKB2) Antibody
 • MAP2K6 Antibody
 • DAPP1 (Ab-139) Antibody
 • Connexin 43 (Phospho-Ser261) (GJA1) Antibody
 • Neurokinin B (NKB) ELISA Kit
 • A1-Microglobulin (A1-MG) ELISA Kit
 • Macro Creatine Kinase (MACRO-CK) ELISA Kit
 • Dermatan Sulfate (DS) ELISA Kit
 • Epiligrin ELISA Kit
 • Insulin Like Growth Factor1 (IGF1) ELISA Kit
 • Platelet Membrane Glycoprotein IV (GP-4) ELISA Kit
 • Heat Shock Protein 27 Antibody (HSP27-AB) ELISA Kit
 • Phosphoinositide-Specific Phospholipase C (PIPLC) ELISA Kit
 • Free Haemoglobin (F-HB) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

TRAF1 sirna

Scan QR to view Datasheet Catalog #    MBS8239859 TRAF1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRAF1, siRNA

 Also Known As   

TRAF1 siRNA (Mouse)

 Product Synonym Names    TNF receptor-associated factor 1
 Product Gene Name   

TRAF1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for P39428
 Host    Synthetic
 Species Reactivity    Mouse
Section Bar
 Specificity    TRAF1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
Section Bar
 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse TRAF1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of TRAF1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for TRAF1 sirna

   siRNA to inhibit TRAF1 expression using RNA interference
 Applications Tested/Suitable for TRAF1 sirna   

RNA Interference (RNAi)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TRAF1. It may not necessarily be applicable to this product.
 NCBI GI #    31981953
 NCBI GeneID    22029
 NCBI Accession #    NP_033447.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009421.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P39428 [Other Products]
 UniProt Secondary Accession #    Q8CE28 [Other Products]
 UniProt Related Accession #    P39428 [Other Products]
 Molecular Weight    45,465 Da
Table BarTOPTable Bar
 NCBI Official Full Name    TNF receptor-associated factor 1
 NCBI Official Synonym Full Names    TNF receptor-associated factor 1
 NCBI Official Symbol    Traf1 [Similar Products]
 NCBI Official Synonym Symbols   
4732496E14Rik
[Similar Products]
 NCBI Protein Information    TNF receptor-associated factor 1
 UniProt Protein Name    TNF receptor-associated factor 1
 Protein Family    TNF receptor-associated factor
 UniProt Gene Name    Traf1 [Similar Products]
 UniProt Entry Name    TRAF1_MOUSE
Section Bar
 UniProt Comments for TRAF1    TRAF1: Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with NFATC2IP, TRAFD1 and with HIVEP3. Interacts with MAP3K14. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Adaptor/scaffold

Cellular Component: cytoplasm

Molecular Function: protein binding; zinc ion binding; thioesterase binding; ubiquitin protein ligase binding; tumor necrosis factor receptor binding

Biological Process: regulation of apoptosis; apoptosis; signal transduction; activation of NF-kappaB transcription factor
Table BarTOPTable Bar
 Research Articles on TRAF1    1. TRAF1 is a crucial early mediator of hepatic ischemia/reperfusion injury.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with TRAF1 sirnaPathways associated with TRAF1 sirna
 Reference Product  PubMed Publications
 Traf2 sirna  >225 publications with TRAF1 and Traf2
 Cd40 sirna  >81 publications with TRAF1 and Cd40
 Casp8 sirna  >55 publications with TRAF1 and Casp8
 Ripk1 sirna  >34 publications with TRAF1 and Ripk1
 Cflar sirna  >14 publications with TRAF1 and Cflar
 Birc2 sirna  >12 publications with TRAF1 and Birc2
 Birc3 sirna  >7 publications with TRAF1 and Birc3
 Tnfrsf1b sirna  >3 publications with TRAF1 and Tnfrsf1b
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 EBV LMP1 Signaling Pathway antibodies  EBV LMP1 Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Oxidative Damage Pathway antibodies  Oxidative Damage Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Small Cell Lung Cancer Pathway antibodies  Small Cell Lung Cancer Pathway Diagram
Diseases associated with TRAF1 sirnaOrgans/Tissues associated with TRAF1 sirna
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >417 publications with TRAF1 and Necrosis
 Arthritis, Rheumatoid Antibodies  >87 publications with TRAF1 and Arthritis, Rheumatoid
 Inflammation Antibodies  >62 publications with TRAF1 and Inflammation
 Carcinoma Antibodies  >32 publications with TRAF1 and Carcinoma
 Nervous System Diseases Antibodies  >18 publications with TRAF1 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >17 publications with TRAF1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >16 publications with TRAF1 and Lung Diseases
 Gastrointestinal Diseases Antibodies  >14 publications with TRAF1 and Gastrointestinal Diseases
 Cell Transformation, Neoplastic Antibodies  >14 publications with TRAF1 and Cell Transformation, Neoplastic
 Hyperplasia Antibodies  >9 publications with TRAF1 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >17 publications with TRAF1 and Skin
 Lung Antibodies  >15 publications with TRAF1 and Lung
 Lymph Node Antibodies  >13 publications with TRAF1 and Lymph Node
 Bone Marrow Antibodies  >12 publications with TRAF1 and Bone Marrow
 Spleen Antibodies  >12 publications with TRAF1 and Spleen
 Thymus Antibodies  >4 publications with TRAF1 and Thymus
 Bladder Antibodies  >2 publications with TRAF1 and Bladder
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions