NP_997491.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
128,602 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily A member 1
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily A, member 1
NCBI Official Synonym Symbols
NCBI Protein Information
transient receptor potential cation channel subfamily A member 1
UniProt Protein Name
Transient receptor potential cation channel subfamily A member 1
UniProt Synonym Protein Names
Ankyrin-like with transmembrane domains protein 1
UniProt Synonym Gene Names
UniProt Entry Name
TRPA1_RAT
UniProt Comments for TRPA1
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:14712238). Is also activated by menthol (in vitro) (). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system ().
Research Articles on TRPA1
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Products associated with TRPA1 sirna
Pathways associated with TRPA1 sirna
Diseases associated with TRPA1 sirna
Organs/Tissues associated with TRPA1 sirna
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