NP_001012496.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,121 Da
NCBI Official Full Name
splicing factor U2AF 65 kDa subunit isoform b
NCBI Official Synonym Full Names
U2 small nuclear RNA auxiliary factor 2
NCBI Official Synonym Symbols
NCBI Protein Information
splicing factor U2AF 65 kDa subunit
UniProt Protein Name
Splicing factor U2AF 65 kDa subunit
UniProt Synonym Protein Names
U2 auxiliary factor 65 kDa subunit; hU2AF(65); hU2AF65; U2 snRNP auxiliary factor large subunit
UniProt Synonym Gene Names
UniProt Entry Name
U2AF2_HUMAN
NCBI Summary for U2AF2
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]
UniProt Comments for U2AF2
U2AF2: Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA splicing; Spliceosome; RNA-binding
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component: nucleoplasm; spliceosome; nuclear speck
Molecular Function: protein binding; enzyme binding; nucleotide binding
Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; positive regulation of RNA splicing; termination of RNA polymerase II transcription
Research Articles on U2AF2
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Products associated with U2AF2 sirna
Pathways associated with U2AF2 sirna
Diseases associated with U2AF2 sirna
Organs/Tissues associated with U2AF2 sirna
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