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USP10 sirna

Scan QR to view Datasheet Catalog #    MBS8206202 USP10 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

USP10, siRNA

 Also Known As   

USP10 siRNA (Human)

 Product Synonym Names    KIAA0190; Ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
 Product Gene Name   

USP10 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609818
 3D Structure    ModBase 3D Structure for Q14694
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    USP10 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human USP10 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of USP10 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for USP10 sirna

   siRNA to inhibit USP10 expression using RNA interference
 Applications Tested/Suitable for USP10 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for USP10. It may not necessarily be applicable to this product.
 NCBI GI #    440918695
 NCBI GeneID    9100
 NCBI Accession #    NP_001259004.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001272075.1 [Other Products]
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 UniProt Primary Accession #    Q14694 [Other Products]
 UniProt Secondary Accession #    Q9BWG7; Q9NSL7; B2RDJ8; B4DS84 [Other Products]
 UniProt Related Accession #    Q14694 [Other Products]
 Molecular Weight    87,533 Da
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase 10 isoform 1
 NCBI Official Synonym Full Names    ubiquitin specific peptidase 10
 NCBI Official Symbol    USP10 [Similar Products]
 NCBI Official Synonym Symbols   
UBPO
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase 10
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase 10
 UniProt Synonym Protein Names   
Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10
 UniProt Gene Name    USP10 [Similar Products]
 UniProt Synonym Gene Names    KIAA0190 [Similar Products]
 UniProt Entry Name    UBP10_HUMAN
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 NCBI Summary for USP10    Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
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 UniProt Comments for USP10    USP10: a carboxyl-terminal ubiquitin-processing protease. Ras-GAP SH3 domain-binding protein (G3BP) appears to inhibit its ability to disassemble ubiquitin chains.

Protein type: EC 3.4.19.12; RNA-binding; Ubiquitin-specific protease; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: early endosome; cytoplasm; nucleus

Molecular Function: protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; DNA damage response, signal transduction by p53 class mediator; autophagy; regulation of autophagy; DNA repair
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 Research Articles on USP10    1. miR-191 could promote pancreatic cancer progression through targeting USP10, implicating a novel mechanism for the tumorigenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with USP10 sirnaPathways associated with USP10 sirna
 Reference Product  PubMed Publications
 G3BP1 sirna  >8 publications with USP10 and G3BP1
 CFTR sirna  >4 publications with USP10 and CFTR
 USP6 sirna  >2 publications with USP10 and USP6
 G3BP2 sirna  >2 publications with USP10 and G3BP2
 USP32 sirna  >1 publications with USP10 and USP32
 Products by Pathway  Pathway Diagram
 DNA Damage Bypass Pathway antibodies  DNA Damage Bypass Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Termination Of Translesion DNA Synthesis Pathway antibodies  Termination Of Translesion DNA Synthesis Pathway Diagram
 Translesion Synthesis By Y Family DNA Polymerases Bypasses Lesions On DNA Template Pathway antibodies  Translesion Synthesis By Y Family DNA Polymerases Bypasses Lesions On DNA Template Pathway Diagram
Diseases associated with USP10 sirnaOrgans/Tissues associated with USP10 sirna
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >6 publications with USP10 and Carcinoma
 Fibrosis Antibodies  >5 publications with USP10 and Fibrosis
 Neoplasms, Experimental Antibodies  >3 publications with USP10 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >2 publications with USP10 and Disease Models, Animal
 Prostatic Diseases Antibodies  >2 publications with USP10 and Prostatic Diseases
 Liver Diseases Antibodies  >2 publications with USP10 and Liver Diseases
 Inflammation Antibodies  >2 publications with USP10 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with USP10 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with USP10 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with USP10 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with USP10 and Blood
 Kidney Antibodies  >4 publications with USP10 and Kidney
 Prostate Antibodies  >3 publications with USP10 and Prostate
 Lung Antibodies  >3 publications with USP10 and Lung
 Liver Antibodies  >2 publications with USP10 and Liver
 Uncharacterized Tissue Antibodies  >2 publications with USP10 and Uncharacterized Tissue
 Stomach Antibodies  >2 publications with USP10 and Stomach
 Thyroid Antibodies  >1 publications with USP10 and Thyroid
 Bone Marrow Antibodies  >1 publications with USP10 and Bone Marrow
 Eye Antibodies  >1 publications with USP10 and Eye
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