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WARS sirna

Scan QR to view Datasheet Catalog #    MBS8229144 WARS sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WARS, siRNA

 Also Known As   

WARS siRNA (Human)

 Product Synonym Names    IFI53; WRS; Tryptophan--tRNA ligase cytoplasmic; Interferon-induced protein 53; IFP53; Tryptophanyl-tRNA synthetase; TrpRS; hWRS
 Product Gene Name   

WARS sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191050
 3D Structure    ModBase 3D Structure for P23381
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    WARS siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human WARS gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of WARS sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for WARS sirna

   siRNA to inhibit WARS expression using RNA interference
 Applications Tested/Suitable for WARS sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for WARS. It may not necessarily be applicable to this product.
 NCBI GI #    47419914
 NCBI GeneID    7453
 NCBI Accession #    NP_004175.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004184.3 [Other Products]
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 UniProt Primary Accession #    P23381 [Other Products]
 UniProt Secondary Accession #    P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3; A6NGN1; A6NID3 [Other Products]
 UniProt Related Accession #    P23381 [Other Products]
 Molecular Weight    48,852 Da
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 NCBI Official Full Name    tryptophan--tRNA ligase, cytoplasmic isoform a
 NCBI Official Synonym Full Names    tryptophanyl-tRNA synthetase
 NCBI Official Symbol    WARS [Similar Products]
 NCBI Official Synonym Symbols   
IFI53; IFP53; GAMMA-2
[Similar Products]
 NCBI Protein Information    tryptophan--tRNA ligase, cytoplasmic
 UniProt Protein Name    Tryptophan--tRNA ligase, cytoplasmic
 UniProt Synonym Protein Names   
Interferon-induced protein 53; IFP53
 Protein Family    Tryptophan--tRNA ligase
 UniProt Gene Name    WARS [Similar Products]
 UniProt Synonym Gene Names    IFI53; WRS; IFP53; TrpRS; hWRS [Similar Products]
 UniProt Entry Name    SYWC_HUMAN
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 NCBI Summary for WARS    Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WARS    WARS: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation; EC 6.1.1.2; Amino Acid Metabolism - tryptophan; Ligase

Chromosomal Location of Human Ortholog: 14q32.31

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; tryptophan-tRNA ligase activity; ATP binding

Biological Process: negative regulation of cell proliferation; tryptophanyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; translation; gene expression; angiogenesis; regulation of angiogenesis
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 Research Articles on WARS    1. Genes within recently identified loci associated with waist-hip ratio (WHR) exhibit fat depot-specific mRNA expression, which correlates with obesity-related traits. Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3, GRB14)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with WARS sirnaPathways associated with WARS sirna
 Reference Product  PubMed Publications
 MARS sirna  >82 publications with WARS and MARS
 UBC sirna  >31 publications with WARS and UBC
 TARS sirna  >8 publications with WARS and TARS
 YARS sirna  >1 publications with WARS and YARS
 WARS2 sirna  >1 publications with WARS and WARS2
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
Diseases associated with WARS sirnaOrgans/Tissues associated with WARS sirna
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3907 publications with WARS and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1652 publications with WARS and Cardiovascular Diseases
 Pain Antibodies  >992 publications with WARS and Pain
 Poisoning Antibodies  >941 publications with WARS and Poisoning
 Heart Diseases Antibodies  >738 publications with WARS and Heart Diseases
 Hemorrhage Antibodies  >558 publications with WARS and Hemorrhage
 Inflammation Antibodies  >367 publications with WARS and Inflammation
 Hypertension Antibodies  >327 publications with WARS and Hypertension
 Memory Disorders Antibodies  >276 publications with WARS and Memory Disorders
 Kidney Diseases Antibodies  >271 publications with WARS and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3109 publications with WARS and Blood
 Brain Antibodies  >3029 publications with WARS and Brain
 Bone Antibodies  >1303 publications with WARS and Bone
 Heart Antibodies  >1028 publications with WARS and Heart
 Skin Antibodies  >975 publications with WARS and Skin
 Lung Antibodies  >939 publications with WARS and Lung
 Vascular Antibodies  >905 publications with WARS and Vascular
 Nerve Antibodies  >830 publications with WARS and Nerve
 Eye Antibodies  >766 publications with WARS and Eye
 Muscle Antibodies  >536 publications with WARS and Muscle
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